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GRB10 Antikörper

Der Kaninchen Polyklonal Anti-GRB10-Antikörper wurde für WB, ELISA, IHC und IF validiert. Er ist geeignet, GRB10 in Proben von Human, Maus und Ratte zu detektieren.
Produktnummer ABIN7114781

Kurzübersicht für GRB10 Antikörper (ABIN7114781)

Target

Alle GRB10 Antikörper anzeigen
GRB10 (Growth Factor Receptor-Bound Protein 10 (GRB10))

Reaktivität

  • 48
  • 8
  • 8
  • 2
  • 1
Human, Maus, Ratte

Wirt

  • 42
  • 6
  • 1
Kaninchen

Klonalität

  • 45
  • 4
Polyklonal

Konjugat

  • 39
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser GRB10 Antikörper ist unkonjugiert

Applikation

  • 34
  • 18
  • 15
  • 14
  • 6
  • 5
  • 4
  • 3
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)
  • Aufreinigung

    Immunogen affinity purified

    Reinheit

    ≥95 % as determined by SDS-PAGE

    Immunogen

    growth factor receptor-bound protein 10

    Isotyp

    IgG
  • Applikationshinweise

    WB: 1:500-1:2000, IHC: 1:20-1:200, IF: 1:20-1:200

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Buffer

    PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    -20 °C

    Informationen zur Lagerung

    -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

    Haltbarkeit

    12 months
  • Target

    GRB10 (Growth Factor Receptor-Bound Protein 10 (GRB10))

    Andere Bezeichnung

    GRB10

    Hintergrund

    Synonyms:Grb 10, GRB IR, GRB10, GRB10 adapter protein, GRBIR, IRBP, KIAA0207, MEG1, RSS Background:Adapter protein which modulates coupling of a number of cell surface receptor kinases with specific signaling pathways. Binds to, and suppress signals from, activated receptors tyrosine kinases, including the insulin(INSR) and insulin-like growth factor(IGF1R) receptors. The inhibitory effect can be achieved by 2 mechanisms: interference with the signaling pathway and increased receptor degradation. Delays and reduces AKT1 phosphorylation in response to insulin stimulation. Blocks association between INSR and IRS1 and IRS2 and prevents insulin-stimulated IRS1 and IRS2 tyrosine phosphorylation. Recruits NEDD4 to IGF1R, leading to IGF1R ubiquitination, increased internalization and degradation by both the proteasomal and lysosomal pathways. May play a role in mediating insulin-stimulated ubiquitination of INSR, leading to proteasomal degradation. Negatively regulates Wnt signaling by interacting with LRP6 intracellular portion and interfering with the binding of AXIN1 to LRP6. Positive regulator of the KDR/VEGFR-2 signaling pathway. May inhibit NEDD4-mediated degradation of KDR/VEGFR-2.

    Molekulargewicht

    65 kDa

    Gen-ID

    2887

    UniProt

    Q13322

    Pathways

    Regulation of Carbohydrate Metabolic Process, Signaling Events mediated by VEGFR1 and VEGFR2
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