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CYLD Antikörper

Dieses Anti-CYLD-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von CYLD in WB, ELISA, IHC und IP. Geeignet für Human, Maus und Ratte.
Produktnummer ABIN7113186

Kurzübersicht für CYLD Antikörper (ABIN7113186)

Target

Alle CYLD Antikörper anzeigen
CYLD (Cylindromatosis (Turban Tumor Syndrome) (CYLD))

Reaktivität

  • 44
  • 21
  • 16
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Human, Maus, Ratte

Wirt

  • 37
  • 7
  • 1
Kaninchen

Klonalität

  • 38
  • 7
Polyklonal

Konjugat

  • 21
  • 3
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser CYLD Antikörper ist unkonjugiert

Applikation

  • 30
  • 13
  • 8
  • 5
  • 5
  • 4
  • 4
  • 4
  • 1
  • 1
  • 1
  • 1
Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunoprecipitation (IP)
  • Aufreinigung

    Immunogen affinity purified

    Reinheit

    ≥95 % as determined by SDS-PAGE

    Immunogen

    cylindromatosis(turban tumor syndrome)

    Isotyp

    IgG
  • Applikationshinweise

    WB: 1:500-1:1000, IP: 1:200-1:1000, IHC: 1:50-1:500

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Buffer

    PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    -20 °C

    Informationen zur Lagerung

    -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

    Haltbarkeit

    12 months
  • Target

    CYLD (Cylindromatosis (Turban Tumor Syndrome) (CYLD))

    Andere Bezeichnung

    CYLD

    Hintergrund

    Synonyms:CYLD1, KIAA0849 Background:Protease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Has endodeubiquitinase activity. Plays an important role in the regulation of pathways leading to NF-kappa-B activation(PubMed:12917689, PubMed:12917691). Contributes to the regulation of cell survival, proliferation and differentiation via its effects on NF-kappa-B activation(PubMed:12917690). Negative regulator of Wnt signaling(PubMed:20227366). Inhibits HDAC6 and thereby promotes acetylation of alpha-tubulin and stabilization of microtubules(PubMed:19893491). Plays a role in the regulation of microtubule dynamics, and thereby contributes to the regulation of cell proliferation, cell polarization, cell migration, and angiogenesis(PubMed:18222923, PubMed:20194890). Required for normal cell cycle progress and normal cytokinesis(PubMed:17495026, PubMed:19893491). Inhibits nuclear translocation of NF-kappa-B. Plays a role in the regulation of inflammation and the innate immune response, via its effects on NF-kappa-B activation(PubMed:18636086). Dispensable for the maturation of intrathymic natural killer cells, but required for the continued survival of immature natural killer cells. Negatively regulates TNFRSF11A signaling and osteoclastogenesis(By similarity). Involved in the regulation of ciliogenesis, allowing ciliary basal bodies to migrate and dock to the plasma membrane, this process does not depend on NF-kappa-B activation(By similarity).

    Molekulargewicht

    110 kDa

    UniProt

    Q9NQC7

    Pathways

    Apoptose, Activation of Innate immune Response
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