CD44 Antikörper (AA 28-380)

Produktnummer ABIN7112500

Dieses Maus Monoklonal-Antikörper erkennt spezifisch CD44 in FACS, WB, IHC, ELISA und IF. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für CD44 Antikörper (AA 28-380) (ABIN7112500)

Target: CD44

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser CD44 Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS), Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

Klon: 7D6

Produktdetails anti-CD44 Antikörper

Bindungsspezifität: AA 28-380

Verwendungszweck: CD44 antibody

Aufreinigung: Protein A+G purification

Reinheit: ≥95 % as determined by SDS-PAGE

Immunogen:

Immunogen sequence: 28-380aa

Immunogen: CD44 molecule(Indian blood group)

Isotyp: IgG2a

Anwendungsinformationen

Applikationshinweise: WB: 1:500-1:5000, IHC: 1:50-1:200, IF: 1:10-1:100

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze / thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: -20°C for 12 months

Haltbarkeit: 12 months

Details zu CD44

Target: CD44

Andere Bezeichnung: CD44

Hintergrund:

Synonyms: CD44 antigen|CDw44|Epican|Extracellular matrix receptor III (ECMR-III)|GP90 lymphocyte homing/adhesion receptor|HUTCH-I|Heparan sulfate proteoglycan|Hermes antigen|Hyaluronate receptor|Phagocytic glycoprotein 1 (PGP-1)|Phagocytic glycoprotein I (PGP-I)|CD44|LHR|MDU2|MDU3|MIC4

Background: Receptor for hyaluronic acid(HA). Mediates cell-cell and cell-matrix interactions through its affinity for HA, and possibly also through its affinity for other ligands such as osteopontin, collagens, and matrix metalloproteinases(MMPs). Adhesion with HA plays an important role in cell migration, tumor growth and progression. In cancer cells, may play an important role in invadopodia formation. Also involved in lymphocyte activation, recirculation and homing, and in hematopoiesis. Altered expression or dysfunction causes numerous pathogenic phenotypes. Great protein heterogeneity due to numerous alternative splicing and post-translational modification events. Receptor for LGALS9, the interaction enhances binding of SMAD3 to the FOXP3 promoter, leading to up-regulation of FOXP3 expression and increased induced regulatory T(iTreg) cell stability and suppressive function(By similarity).

Molekulargewicht: 80-95 kDa

Gen-ID: 960

UniProt: P16070

Pathways: Glycosaminoglycan Metabolic Process, Autophagie, Negative Regulation of intrinsic apoptotic Signaling