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CARD9 Antikörper

CARD9 Reaktivität: Human, Maus, Ratte WB, ELISA Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN7112379
  • Target Alle CARD9 Antikörper anzeigen
    CARD9 (Caspase Recruitment Domain Family, Member 9 (CARD9))
    Reaktivität
    • 35
    • 3
    • 2
    • 2
    • 2
    • 1
    Human, Maus, Ratte
    Wirt
    • 33
    • 3
    Kaninchen
    Klonalität
    • 35
    • 1
    Polyklonal
    Konjugat
    • 22
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser CARD9 Antikörper ist unkonjugiert
    Applikation
    • 35
    • 13
    • 13
    • 9
    • 8
    • 7
    • 6
    • 5
    • 3
    • 3
    • 1
    • 1
    Western Blotting (WB), ELISA
    Aufreinigung
    Immunogen affinity purified
    Reinheit
    ≥95 % as determined by SDS-PAGE
    Immunogen
    caspase recruitment domain family, member 9
    Isotyp
    IgG
    Top Product
    Discover our top product CARD9 Primärantikörper
  • Applikationshinweise
    WB: 1:500-1:2000
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
    Haltbarkeit
    12 months
  • Target
    CARD9 (Caspase Recruitment Domain Family, Member 9 (CARD9))
    Andere Bezeichnung
    CARD9 (CARD9 Produkte)
    Synonyme
    Gm782 antikoerper, card9 antikoerper, CANDF2 antikoerper, hCARD9 antikoerper, caspase recruitment domain family, member 9 antikoerper, caspase recruitment domain family member 9 antikoerper, Card9 antikoerper, CARD9 antikoerper, card9 antikoerper
    Hintergrund
    Synonyms: Background:Adapter protein that plays a key role in innate immune response to a number of intracellular pathogens, such as C.albicans and L.monocytogenes. Is at the crossroads of ITAM-tyrosine kinase and the Toll-like receptors(TLR) and NOD2 signaling pathways. Probably controls various innate immune response pathways depending on the intracellular pathogen. In response to L.monocytogenes infection, acts by connecting NOD2 recognition of peptidoglycan to downstream activation of MAP kinases(MAPK) without activating NF-kappa-B. Also involved in activation of myeloid cells via classical ITAM-associated receptors and TLR: required for TLR-mediated activation of MAPK, while it is not required for TLR-induced activation of NF-kappa-B(By similarity). Controls CLEC7A(dectin-1)-mediated myeloid cell activation induced by the yeast cell wall component zymosan, leading to cytokine production and innate anti-fungal immunity: acts by regulating BCL10-MALT1-mediated NF-kappa-B activation pathway. Activates NF-kappa-B via BCL10. In response to the hyphal form of C.albicans, mediates CLEC6A(dectin-2)-induced I-kappa-B kinase ubiquitination, leading to NF-kappa-B activation via interaction with BCL10. In response to fungal infection, may be required for the development and subsequent differentiation of interleukin 17-producing T helper(TH-17) cells.
    Molekulargewicht
    50-59kd
    Gen-ID
    64170
    UniProt
    Q9H257
    Pathways
    Activation of Innate immune Response
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