AMFR Antikörper

Produktnummer ABIN7111885

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch AMFR in WB, IHC, ELISA, IP und IF. Er zeigt eine Reaktivität gegenüber Human, Maus und Ratte.

Kurzübersicht für AMFR Antikörper (ABIN7111885)

Target: AMFR (Autocrine Motility Factor Receptor (AMFR))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser AMFR Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunoprecipitation (IP), Immunofluorescence (IF)

Produktdetails anti-AMFR Antikörper

Aufreinigung: Immunogen affinity purified

Reinheit: ≥95 % as determined by SDS-PAGE

Immunogen: autocrine motility factor receptor

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 1:500-1:5000, IF: 1:10-1:100, IHC: 1:20-1:200, IP: 1:200-1:2000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Haltbarkeit: 12 months

Details zu AMFR

Target: AMFR (Autocrine Motility Factor Receptor (AMFR))

Andere Bezeichnung: AMFR

Hintergrund: Synonyms:AMF receptor, isoform 2, AMFR, GP78, RING finger protein 45, RNF45 Background:E3 ubiquitin-protein ligase that mediates the polyubiquitination of a number of proteins such as CD3D, CYP3A4, CFTR and APOB for proteasomal degradation. Component of a VCP/p97-AMFR/gp78 complex that participates in the final step of endoplasmic reticulum-associated degradation(ERAD). The VCP/p97-AMFR/gp78 complex is involved in the sterol-accelerated ERAD degradation of HMGCR through binding to the HMGCR-INSIG complex at the ER membrane and initiating ubiquitination of HMGCR. The ubiquitinated HMGCR is then released from the ER by the complex into the cytosol for subsequent destruction. Also acts as a scaffold protein to assemble a complex that couples ubiquitination, retranslocation and deglycosylation. Mediates tumor invasion and metastasis as a receptor for the GPI/autocrine motility factor.

Molekulargewicht: 73 kDa

Gen-ID: 267

UniProt: Q9UKV5

Pathways: ER-Nucleus Signaling