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ADAM17 Antikörper (AA 201-300)

Der Kaninchen Polyklonal Anti-ADAM17-Antikörper wurde für WB, ELISA, FACS, IF (cc), IF (p), IHC (p) und IHC (fro) validiert. Er ist geeignet, ADAM17 in Proben von Human, Ratte und Maus zu detektieren. Es ist 1 Publikation verfügbar.
Produktnummer ABIN705671

Kurzübersicht für ADAM17 Antikörper (AA 201-300) (ABIN705671)

Target

Alle ADAM17 Antikörper anzeigen
ADAM17 (ADAM Metallopeptidase Domain 17 (ADAM17))

Reaktivität

  • 111
  • 49
  • 46
  • 3
  • 3
  • 3
  • 1
Human, Ratte, Maus

Wirt

  • 91
  • 22
  • 1
  • 1
  • 1
  • 1
Kaninchen

Klonalität

  • 82
  • 35
Polyklonal

Konjugat

  • 63
  • 8
  • 7
  • 5
  • 4
  • 3
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser ADAM17 Antikörper ist unkonjugiert

Applikation

  • 89
  • 47
  • 38
  • 22
  • 19
  • 14
  • 13
  • 13
  • 12
  • 9
  • 4
  • 3
  • 3
  • 2
  • 1
Western Blotting (WB), ELISA, Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
  • Bindungsspezifität

    • 15
    • 10
    • 8
    • 8
    • 7
    • 5
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 201-300

    Kreuzreaktivität

    Human, Maus, Ratte

    Homologie

    Dog,Cow,Pig,Rabbit

    Aufreinigung

    Purified by Protein A.

    Immunogen

    KLH conjugated synthetic peptide derived from human ADAM17

    Isotyp

    IgG
  • Applikationshinweise

    WB 1:300-5000
    ELISA 1:500-1000
    FCM 1:20-100
    IHC-P 1:200-400
    IHC-F 1:100-500
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Konzentration

    1 μg/μL

    Buffer

    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

    Konservierungsmittel

    ProClin

    Vorsichtsmaßnahmen

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

    Lagerung

    4 °C,-20 °C

    Informationen zur Lagerung

    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

    Haltbarkeit

    12 months
  • Li, Xie, He, Wang, Duan, Yang, Wang: "Identification of ADAM10 and ADAM17 with potential roles in the spermatogenesis of the Chinese mitten crab, Eriocheir sinensis." in: Gene, Vol. 562, Issue 1, pp. 117-27, (2015) (PubMed).

  • Target

    ADAM17 (ADAM Metallopeptidase Domain 17 (ADAM17))

    Andere Bezeichnung

    ADAM17

    Hintergrund

    Synonyms: CSVP, TACE, NISBD, ADAM18, CD156B, NISBD1, Disintegrin and metalloproteinase domain-containing protein 17, ADAM 17, Snake venom-like protease, TNF-alpha convertase, TNF-alpha-converting enzyme, ADAM17

    Background: Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1 and the amyloid precursor protein. Acts as an activator of Notch pathway by mediating cleavage of Notch, generating the membrane-associated intermediate fragment called Notch extracellular truncation (NEXT). Plays a role in the proteolytic processing of ACE2.

    Gen-ID

    6868

    UniProt

    P78536

    Pathways

    Notch Signalweg, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Response to Growth Hormone Stimulus
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