MYLK3 Antikörper

Produktnummer ABIN7074736

Dieses Anti-MYLK3-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von MYLK3 in IHC und IF. Geeignet für Maus und Ratte.

Kurzübersicht für MYLK3 Antikörper (ABIN7074736)

Target: MYLK3 (Myosin Light Chain Kinase 3 (MYLK3))

Reaktivität: Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MYLK3 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC), Immunofluorescence (IF)

Produktdetails anti-MYLK3 Antikörper

Kreuzreaktivität: Ratte

Aufreinigung: Affinity purification

Immunogen: Recombinant protein corresponding to Mouse MYLK3/MLCK

Anwendungsinformationen

Applikationshinweise: IHC/IF (M,R) 1:600-1:1200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS, pH 7.4, 0.02 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Details zu MYLK3

Target: MYLK3 (Myosin Light Chain Kinase 3 (MYLK3))

Andere Bezeichnung: MYLK3/MLCK

Hintergrund: The Ca2+/calmodulin-dependent protein kinases (CaM kinases) are a structurally related subfamily of serine/threonine kinases that includes CaMKI, CaMKII, CaMKIV and Myosin light chain kinases (MYLKs, also designated MLCKs). The MYLK kinases phosphorylate Myosin regulatory light chains to catalyze Myosin interaction with Actin filaments, resulting in contractile activity. MYLK3 (Myosin light chain kinase 3) is a 795 amino acid cardiac-specific protein that contains one protein kinase domain and belongs to the protein kinase superfamily. Like other MYLK kinases, MYLK3 is thought to play a role in smooth muscle contraction, specifically using magnesium as a cofactor to catalyze the ATP-dependent phosphorylation of Myosin light chain proteins. Additionally, MYLK3 may regulate sarcomere assembly in heart tissue, possibly mediating proper heart function.

Gen-ID: 213435

NCBI Accession: NP_001284541

UniProt: Q3UIZ8

Pathways: Regulation of Muscle Cell Differentiation