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MYLK3 Antikörper (AA 40-69)

MYLK3 Reaktivität: Human, Maus WB, IHC, ELISA Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN3031919
  • Target Alle MYLK3 Antikörper anzeigen
    MYLK3 (Myosin Light Chain Kinase 3 (MYLK3))
    Bindungsspezifität
    • 8
    • 7
    • 7
    • 7
    • 6
    • 6
    • 2
    • 2
    • 1
    • 1
    • 1
    AA 40-69
    Reaktivität
    • 45
    • 35
    • 18
    • 1
    • 1
    • 1
    • 1
    Human, Maus
    Wirt
    • 54
    Kaninchen
    Klonalität
    • 54
    Polyklonal
    Konjugat
    • 20
    • 5
    • 5
    • 5
    • 4
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser MYLK3 Antikörper ist unkonjugiert
    Applikation
    • 50
    • 28
    • 24
    • 4
    • 3
    • 2
    • 2
    Western Blotting (WB), Immunohistochemistry (IHC), ELISA
    Aufreinigung
    Purified
    Immunogen
    A portion of amino acids 40-69 from the human protein was used as the immunogen for this MYLK3 antibody.
    Isotyp
    Ig Fraction
    Top Product
    Discover our top product MYLK3 Primärantikörper
  • Applikationshinweise
    Titration of the MYLK3 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000,IHC (Paraffin): 1:50-1:100
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    In 1X PBS pH 7.4 with 0.09 % sodium azide
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Aliquot the MYLK3 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
  • Target
    MYLK3 (Myosin Light Chain Kinase 3 (MYLK3))
    Andere Bezeichnung
    MYLK3 (MYLK3 Produkte)
    Synonyme
    MLCK antikoerper, MLCK2 antikoerper, caMLCK antikoerper, D830007F02Rik antikoerper, RGD1305801 antikoerper, myosin light chain kinase 3 antikoerper, MYLK3 antikoerper, Mylk3 antikoerper
    Hintergrund
    MLCK/MYLK3, a member of the Ser/Thr protein kinase family, is a calcium/calmodulin-dependent enzyme responsible for smooth muscle contraction via phosphorylation of a specific serine in the N-terminus of myosin light chains (MLC), an event that facilitates myosin interaction with actin filaments. It is a central determinant in the development of vascular permeability and tissue edema formation. In the nervous system it has been shown to control the growth initiation of astrocytic processes in culture and to participate in transmitter release at synapses formed between cultured sympathetic ganglion cells. MLCK acts as a critical participant in signaling sequences that result in fibroblast apoptosis. Smooth muscle and non-muscle isozymes are expressed in a wide variety of adult and fetal tissues and in cultured endothelium with qualitative expression appearing to be neither tissue- nor development-specific. Non-muscle isoform 2 is the dominant splice variant expressed in various tissues. The Telokin isoform, which binds calmodulin, has been found in a wide variety of adult and fetal tissues. MLCK is probably down-regulated by phosphorylation. The protein contains 1 fibronectin type III domain and 9 immunoglobulin-like C2-type domains.
    UniProt
    Q32MK0
    Pathways
    Regulation of Muscle Cell Differentiation
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