LAT Antikörper
Kurzübersicht für LAT Antikörper (ABIN7074502)
Target
Alle LAT Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
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Kreuzreaktivität
- Human, Ratte
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Aufreinigung
- Affinity purification
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Immunogen
- Recombinant protein corresponding to Mouse LAT
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anti-Linker For Activation of T Cells (LAT) (Cytoplasmic Domain) antibody
LAT Reaktivität: Human WB, IP, ICFC Wirt: Maus Monoclonal LAT-01 unconjugated
anti-Linker For Activation of T Cells (LAT) (pTyr191) antibodyLAT Reaktivität: Human WB, ELISA, IHC, IP, IF Wirt: Kaninchen Monoclonal 2E4 unconjugated Recombinant Antibody
anti-Linker For Activation of T Cells (LAT) antibodyKD Validated LAT Reaktivität: Human WB, FACS Wirt: Kaninchen Monoclonal 24GB4940 unconjugated Recombinant Antibody
anti-Linker For Activation of T Cells (LAT) (pTyr226) antibodyLAT Reaktivität: Human WB, IHC (f) Wirt: Maus Monoclonal J96-1238-58-93 unconjugated
anti-Linker For Activation of T Cells (LAT) (AA 1-233) antibodyLAT Reaktivität: Human WB, ELISA, IHC (p) Wirt: Maus Monoclonal 3B11-1D5 unconjugated
anti-Linker For Activation of T Cells (LAT) (AA 30-237) antibodyLAT Reaktivität: Maus WB, IHC, IP, ICC Wirt: Kaninchen Polyclonal unconjugated
anti-Linker For Activation of T Cells (LAT) (pTyr161) antibodyLAT Reaktivität: Human ELISA, IF (p), IF (cc), IHC (p), IHC (fro) Wirt: Kaninchen Polyclonal unconjugated
anti-Linker For Activation of T Cells (LAT) (Cytoplasmic Domain) antibodyLAT Reaktivität: Human WB, IHC, IP, IHC (p) Wirt: Maus Monoclonal LAT1111 unconjugated
anti-Linker For Activation of T Cells (LAT) (AA 25-221) antibodyLAT Reaktivität: Human WB, IHC, IP, ICC Wirt: Kaninchen Polyclonal unconjugated
anti-Linker For Activation of T Cells (LAT) (AA 33-227) antibodyLAT Reaktivität: Ratte WB, IHC, IP, ICC Wirt: Kaninchen Polyclonal unconjugated
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Applikationshinweise
- WB (M,R) 1:500-1:1000, IHC/IF (H,M,R) 1:1000-1:4000/1:500-1:3000
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Liquid
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Buffer
- PBS, pH 7.4, 0.02 % sodium azide
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Konservierungsmittel
- Sodium azide
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Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Lagerung
- -20 °C
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- LAT (Linker For Activation of T Cells (LAT))
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Andere Bezeichnung
- LAT
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Hintergrund
- Linker for activation of T-cells family member 1 (LAT) is a single-pass type III membrane protein which is required for TCR (T-cell antigen receptor) and pre-TCR-mediated signaling, both in mature T-cells and during their development This protein is involved in FCGR3 (low affinity immunoglobulin gamma Fc region receptor III)-mediated signaling in natural killer cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Functionally T cell receptor (TCR) activation results in tyrosine phosphorylation of LAT, leading to the direct interaction with several proteins, including PLC-gamma 1, Grb2 and Gads. These direct ligands then mediate the indirect interaction of LAT with proteins such as SLP-76, Vav1 and Itk. PLC-gamma 1, Vav1 and Itk contain pleckstrin homology (PH) domains that interact with the enzymatic product of phosphoinositide-3-kinase (PI3k).
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Molekulargewicht
- 38 kDa
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Gen-ID
- 16797
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NCBI Accession
- NP_034819
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UniProt
- O54957
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Pathways
- T-Zell Rezeptor Signalweg, Fc-epsilon Rezeptor Signalübertragung
Target
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