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LAT Antikörper

Dieses Anti-LAT-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von LAT in WB, IHC und IF. Geeignet für Human, Maus und Ratte.
Produktnummer ABIN7074502

Kurzübersicht für LAT Antikörper (ABIN7074502)

Target

Alle LAT Antikörper anzeigen
LAT (Linker For Activation of T Cells (LAT))

Reaktivität

  • 129
  • 49
  • 32
  • 1
Human, Maus, Ratte

Wirt

  • 114
  • 20
  • 2
  • 1
Kaninchen

Klonalität

  • 114
  • 23
Polyklonal

Konjugat

  • 79
  • 5
  • 4
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 1
  • 1
  • 1
  • 1
Dieser LAT Antikörper ist unkonjugiert

Applikation

  • 87
  • 48
  • 39
  • 39
  • 22
  • 22
  • 15
  • 12
  • 9
  • 6
  • 4
  • 3
  • 2
  • 1
  • 1
  • 1
  • 1
Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
  • Kreuzreaktivität

    Human, Ratte

    Aufreinigung

    Affinity purification

    Immunogen

    Recombinant protein corresponding to Mouse LAT
  • Applikationshinweise

    WB (M,R) 1:500-1:1000, IHC/IF (H,M,R) 1:1000-1:4000/1:500-1:3000

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Buffer

    PBS, pH 7.4, 0.02 % sodium azide

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    -20 °C
  • Target

    LAT (Linker For Activation of T Cells (LAT))

    Andere Bezeichnung

    LAT

    Hintergrund

    Linker for activation of T-cells family member 1 (LAT) is a single-pass type III membrane protein which is required for TCR (T-cell antigen receptor) and pre-TCR-mediated signaling, both in mature T-cells and during their development This protein is involved in FCGR3 (low affinity immunoglobulin gamma Fc region receptor III)-mediated signaling in natural killer cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Functionally T cell receptor (TCR) activation results in tyrosine phosphorylation of LAT, leading to the direct interaction with several proteins, including PLC-gamma 1, Grb2 and Gads. These direct ligands then mediate the indirect interaction of LAT with proteins such as SLP-76, Vav1 and Itk. PLC-gamma 1, Vav1 and Itk contain pleckstrin homology (PH) domains that interact with the enzymatic product of phosphoinositide-3-kinase (PI3k).

    Molekulargewicht

    38 kDa

    Gen-ID

    16797

    NCBI Accession

    NP_034819

    UniProt

    O54957

    Pathways

    T-Zell Rezeptor Signalweg, Fc-epsilon Rezeptor Signalübertragung
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