Rekombinanter ITGAL Antikörper

Produktnummer ABIN7072545

Dieses Anti-ITGAL-Antikörper ist ein Kaninchen Chimeric-Antikörper zur Detektion von ITGAL in InhA. Geeignet für Human.

Kurzübersicht für Rekombinanter ITGAL Antikörper (ABIN7072545)

Target: ITGAL (Integrin alpha-L (ITGAL))

Antikörpertyp: Recombinant Antibody

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Chimeric

Konjugat: Dieser ITGAL Antikörper ist unkonjugiert

Applikation: Inhibition Assay (InhA)

Klon: MHM24

Produktdetails anti-ITGAL Antikörper

Verwendungszweck: Anti-CD11a [MHM24], Rabbit IgG, kappa

Spezifität: MHM24 binds to the CD11a subunit of lymphocyte function-associated antigen. It binds to both the high- and low-affinity forms of the antigen.

Produktmerkmale:

Original Species of Ab: Mouse

Original Format of Ab: IgG

Aufreinigung: Protein A affinity purified

Immunogen: Spleen cells from BALB/c mice immunised with EBV-transformed human lymphoblastoid cells were fused with P3-NSUlAg4.1 myeloma cells and the resulting hybridomas were screened for antibody production by a radioimmunoassay on T and B cell lines.

Isotyp: IgG kappa

Anwendungsinformationen

Applikationshinweise: Cytofluorography was used to show the binding of MHM24 to peripheral blood lymphocytes, with 97.3 % of cells stained by MHM24 (Hildreth et al, 1983). In inhibition experiments, MHM24 inhibited T cell-mediated lysis of virus-infected cells (Hildreth et al, 1983). Additionally, MHM24 inhibited NK cell-mediated lysis (Hildreth et al, 1983).Flow cytometry showed MHM24 exhibits non-selective binding to high-affinity and low-affinity forms of LFA-1 (Huang et al, 2006). Murine MHM24 was humanised and shown to prevent adhesion of human T cells to human keratinocytes and the proliferation of T cells in response to nonautologous leukocytes (Werther et al, 1996).

Kommentare:

This chimeric rabbit antibody was made using the variable domain sequences of the original Mouse IgG format, for improved compatibility with existing reagents, assays and techniques.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1 mg/mL

Buffer: PBS with 0.02 % Proclin 300.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.

Details zu ITGAL

Target: ITGAL (Integrin alpha-L (ITGAL))

Andere Bezeichnung: CD11a

Hintergrund: Integrin alpha-L, CD11 antigen-like family member A, leukocyte function-associated molecule 1 alpha chain, human lymphocyte function antigen

UniProt: P20701

Pathways: Activated T Cell Proliferation, Integrin Complex