P2RX1 Antikörper (Extracellular)

Produktnummer ABIN7043571

Produktdetails anti-P2RX1 Antikörper

Target: P2RX1 (Purinergic Receptor P2X, Ligand Gated Ion Channel 1 (P2RX1))

Bindungsspezifität: AA 270-283, Extracellular

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser P2RX1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Flow Cytometry (FACS), Immunofluorescence (IF), Live Cell Imaging (LCI), Immunochromatography (IC)

Verwendungszweck: A Rabbit Polyclonal Antibody to P2X1 Receptor

Spezifität: Extracellular loop

Kreuzreaktivität: Human, Maus, Ratte

Homologie: Rat,mouse - 11,14 amino acid residues identical

Produktmerkmale: Anti-P2X1 Receptor (extracellular) Antibody (ABIN7043571, ABIN7045096 and ABIN7045097) is a highly specific antibody directed against an epitope of the human protein. The antibody can be used in western blot, immunocytochemistry, immunohistochemistry, and indirect flow cytometry applications. It has been designed to recognize P2X1 receptor from rat, mouse, and human samples.

Aufreinigung: Affinity purified on immobilized antigen.

Immunogen:

Immunogen: Synthetic peptide

Immunogen Sequence: CRPIYEFHGLYEEK, corresponding to amino acid residues 270-283 of human P2X1 receptor

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

Antigen preadsorption control: 1 μg peptide per 1 μg antibody

Application Dilutions Immunohistochemistry paraffin embedded sections ihc: N/A

Application Dilutions Western blot wb: 1:200

Kommentare:

Cited Application: IFC

Negative Control: (ABIN7236652)

Blocking Peptide: (ABIN7236652)

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Recosntitute with double distilled water (DDW) to a concentration of 1.0 mg/mL.

Konzentration: 1 mg/mL

Buffer: PBS pH 7.4

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung:

Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.

Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).

Details zu P2RX1

Target: P2RX1 (Purinergic Receptor P2X, Ligand Gated Ion Channel 1 (P2RX1))

Andere Bezeichnung: P2RX1 (P2RX1 Produkte)

Hintergrund: P2RX1, P2X purinoceptor 1,The P2X receptors belong to the ligand-gated ion channel family and are activated by extracellular ATP.The structure and function of the P2X receptors, investigated mainly using in vitro models, indicate their involvement in synaptic communication, cell death, and differentiation.Seven mammalian P2X receptor subtypes (P2X1-P2X7) have been identified and cloned1-3. All P2X receptor subtypes share the same structure of intracellular N- and C-termini two membrane-spanning domains and a large extracellular loop.All P2X receptor subtypes can assemble to form homomeric or heteromeric functional channels with the exception of P2X6, which only seems to function as part of a heteromeric complex4-9.The various P2X receptor subtypes show distinct expression patterns. P2X1-6 have been found in the central and peripheral nervous systems, while the P2X7 receptor is predominantly found in cells of the immune system4. The P2X1 receptor is present in smooth muscle, cerebellum, dorsal horn spinal neurons, and platelets where it is suggested to play a regulatory role during in vivo homeostasis and thrombosis3,4,10,11.

Alternative names: P2X1 Receptor, P2RX1, P2X purinoceptor 1

Gen-ID: 5023

NCBI Accession: NM_002558

UniProt: P51575

Pathways: Positive Regulation of Endopeptidase Activity