NMUR2 Antikörper (Extracellular)

Produktnummer ABIN7043366

Produktdetails anti-NMUR2 Antikörper

Target: NMUR2 (Neuromedin U Receptor 2 (NMUR2))

Bindungsspezifität: AA 3-16, Extracellular

Reaktivität: Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser NMUR2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunochromatography (IC), Immunofluorescence (IF), Live Cell Imaging (LCI)

Verwendungszweck: A Rabbit Polyclonal Antibody to Neuromedin-U Receptor 2

Spezifität: Extracellular, N-terminus

Kreuzreaktivität: Human, Maus, Ratte

Homologie: 14 amino acid residues identical,Mouse -13, human - 7

Produktmerkmale: Anti-NMUR2 (extracellular) Antibody (ABIN7043366, ABIN7044706 and ABIN7044707)) is a highly specific antibody directed against an epitope of the rat Neuromedin-U receptor 2. The antibody can be used in western blot and live cell imaging applications. It has been designed to recognize NMUR2 from rat, human, and mouse samples.

Aufreinigung: Affinity purified on immobilized antigen.

Immunogen:

Immunogen: Synthetic peptide

Immunogen Sequence: (C)KLENASWIHDPLMK, corresponding to amino acid residues 3-16 of rat NMUR2

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

Antigen preadsorption control: 1 μg peptide per 1 μg antibody

Application Dilutions Immunohistochemistry paraffin embedded sections ihc: 1:100

Application Dilutions Western blot wb: 1:200

Kommentare:

Negative Control: BLP-NR072

Blocking Peptide: BLP-NR072

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Recosntitute with double distilled water (DDW) to a concentration of 1.0 mg/mL.

Konzentration: 1 mg/mL

Buffer: PBS pH 7.4

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung:

Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.

Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).

Details zu NMUR2

Target: NMUR2 (Neuromedin U Receptor 2 (NMUR2))

Andere Bezeichnung: NMUR2 (NMUR2 Produkte)

Hintergrund: Neuromedin-U receptor 2, NMU2 Receptor, G-protein coupled receptor TGR-1, G-protein coupled receptor FM-4, TGR1, GPR-FM4, SNORF72,Neuromedin U (NMU) is a highly conserved, ubiquitously distributed neuropeptide, which regulates food intake and body weight. Two high-affinity receptors have been identified for NMU: Neuromedin U receptor 1 (NMUR1) and Neuromedin U receptor 2 (NMUR2) that belong to the G-protein coupled receptors (GPCRs). These receptors are members of the rhodopsin-like class A GPCR family and share about 50 % identity with each other in the seven transmembrane region.NMUR2 is highly expressed in the central nervous system, in the paraventricular nucleus of the hypothalamus, nuclei accumbens, hippocampus, thalamus, medulla oblongata, and spinal cord. It is also detected in organs such as the uterus and ovary, and is abundant in nociceptive sensory pathways, including spinal dorsal horn, dorsal root ganglia, thalamus, and brain stem1-5.Central effects of NMU, including the regulation of food intake, energy balance, stress response, and nociception, are mediated by NMUR2. In the brain, NMUR2 is predominant in the hypothalamic regions that are associated with regulation of food intake and energy balance5. NMUR2 has been suggested as a potential target for developing new therapeutics for the treatment of eating disorders, obesity, stress-related disorders, and pain5.Some studies have demonstrated that NMUR2 signaling in the paraventricular nucleus of the hypothalamus regulates consumption and preference for high-fat foods2.

Alternative names: NMUR2, Neuromedin-U receptor 2, NMU2 Receptor, G-protein coupled receptor TGR-1, G-protein coupled receptor FM-4, TGR1, GPR-FM4, SNORF72

Gen-ID: 64042

NCBI Accession: NM_020167

UniProt: Q9ESQ4

Pathways: Feeding Behaviour