FSHR Antikörper (Extracellular, N-Term)

Produktnummer ABIN7886322

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch FSHR in WB, IHC, IF, IC und LCI. Es zeigt Reaktivität gegenüber Proben von Ratte.

Kurzübersicht für FSHR Antikörper (Extracellular, N-Term) (ABIN7886322)

Target: FSHR (Follicle Stimulating Hormone Receptor (FSHR))

Reaktivität: Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser FSHR Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunochromatography (IC), Live Cell Imaging (LCI)

Produktdetails anti-FSHR Antikörper

Bindungsspezifität: AA 128-140, Extracellular, N-Term

Verwendungszweck: A Rabbit Polyclonal Antibody to FSH Receptor

Kreuzreaktivität: Human, Ratte

Homologie: Mouse,human - 12,13 amino acid residues identical

Produktmerkmale: Anti-FSHR (extracellular) Antibody is directed against an extracellular epitope of the rat FSH receptor. Anti-FSHR (extracellular) Antibody (ABIN7043134, ABIN7044277 and ABIN7044278) can be used in western blot and live cell imaging applications. It has been designed to recognize the FSH receptor from rat, mouse and human samples.

Aufreinigung: Affinity purified on immobilized antigen.

Immunogen: (C)SNTGIKHLPAVHK, corresponding to amino acid residues 128-140 of rat FSHR

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

WB: 1:200

FC: The optimal concentration should be determined by the user

ICC: 1:25

IHC: 1:200

IP: The optimal concentration should be determined by the user

Kommentare:

Negative Control: (ABIN7235325)

Blocking Peptide: (ABIN7235325)

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: 25 μL, 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.

Konzentration: 0.8 mg/mL

Buffer: PBS pH 7.4, 1 % BSA with 0.05 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Details zu FSHR

Target: FSHR (Follicle Stimulating Hormone Receptor (FSHR))

Andere Bezeichnung: FSHR

Hintergrund:

Synonyms: FSH receptor, Follicle-stimulating hormone receptor, Follitropin receptor, FSHRO

Description: FSH (follicle stimulating hormone) is the central hormone of mammalian reproduction, necessary for gonadal development and maturation at puberty and for gamete production during the fertile phase of life1. Together with LH, this gonadotropin is produced and secreted by the pituitary gland as a highly heterogeneous glycoprotein2. The FSH receptor belongs to the family of G-protein coupled receptors, complex transmembrane proteins characterized by seven hydrophobic helices inserted in the plasma membrane and by intracellular and extracellular domains of variable dimensions depending on the type of ligand3. The intracellular portion of the FSH receptor is coupled to a Gs protein and, upon receptor activation by the hormonal interaction with the extracellular domain it initiates a cascade of events that ultimately leads to the specific biological effects of the gonadotropin.FSH acts by binding to specific receptors, localized exclusively in the gonads. The FSH receptor is expressed by two cell types of the gonad, namely Sertoli cells in the testis, and granulosa cells in the ovarian follicle4.Mutations of FSHR may cause primary or secondary amenorrhea, infertility, premature ovarian failure (POF) and ovarian hyperstimulation syndrome (OHSS)5. Mutations of FSHR may also play a role in the development of granulosa cell tumors of ovaries6.

Gen-ID: 25449

NCBI Accession: NM_000145

UniProt: P20395

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Regulation of Hormone Metabolic Process, Platelet-derived growth Factor Receptor Signaling