SOCS2 Antikörper

Produktnummer ABIN7259532

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch SOCS2 in IF. Es zeigt Reaktivität gegenüber Proben von Human.

Kurzübersicht für SOCS2 Antikörper (ABIN7259532)

Target: SOCS2 (Suppressor of Cytokine Signaling 2 (SOCS2))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SOCS2 Antikörper ist unkonjugiert

Applikation: Immunofluorescence (IF)

Produktdetails anti-SOCS2 Antikörper

Produktmerkmale: Polyclonal Antibody

Aufreinigung: Affinity purification

Immunogen: Recombinant fusion protein of human SOCS2 (NP_001257400.1).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IF 1:50-1:100

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu SOCS2

Target: SOCS2 (Suppressor of Cytokine Signaling 2 (SOCS2))

Andere Bezeichnung: SOCS2

Hintergrund: This gene encodes a member of the suppressor of cytokine signaling (SOCS) family. SOCS family members are cytokine-inducible negative regulators of cytokine receptor signaling via the Janus kinase/signal transducer and activation of transcription pathway (the JAK/STAT pathway). SOCS family proteins interact with major molecules of signaling complexes to block further signal transduction, in part, by proteasomal depletion of receptors or signal-transducing proteins via ubiquitination. The expression of this gene can be induced by a subset of cytokines, including erythropoietin, GM-CSF, IL10, interferon (IFN)-gamma and by cytokine receptors such as growth horomone receptor. The protein encoded by this gene interacts with the cytoplasmic domain of insulin-like growth factor-1 receptor (IGF1R) and is thought to be involved in the regulation of IGF1R mediated cell signaling. This gene has pseudogenes on chromosomes 20 and 22. Alternative splicing results in multiple transcript variants.

Gen-ID: 8835

UniProt: O14508

Pathways: JAK-STAT Signalweg, Response to Growth Hormone Stimulus