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beta Catenin Antikörper

CATNB Reaktivität: Human, Maus, Ratte WB, IF, IHC (p) Wirt: Maus Monoclonal 2E4 unconjugated
Produktnummer ABIN7250260
  • Target Alle beta Catenin (CATNB) Antikörper anzeigen
    beta Catenin (CATNB) (Catenin, beta (CATNB))
    Reaktivität
    • 330
    • 247
    • 225
    • 29
    • 23
    • 22
    • 18
    • 18
    • 5
    • 5
    • 5
    • 5
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Maus, Ratte
    Wirt
    • 271
    • 58
    • 4
    • 2
    • 1
    Maus
    Klonalität
    • 266
    • 70
    Monoklonal
    Konjugat
    • 122
    • 22
    • 16
    • 15
    • 15
    • 15
    • 15
    • 15
    • 11
    • 10
    • 9
    • 9
    • 9
    • 9
    • 9
    • 8
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 1
    • 1
    • 1
    Dieser beta Catenin Antikörper ist unkonjugiert
    Applikation
    • 206
    • 158
    • 120
    • 118
    • 74
    • 62
    • 61
    • 48
    • 35
    • 31
    • 22
    • 8
    • 7
    • 4
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Produktmerkmale
    Monoclonal Antibody
    Aufreinigung
    Protein A purification
    Immunogen
    Recombinant Protein
    Klon
    2E4
    Isotyp
    IgG
    Top Product
    Discover our top product CATNB Primärantikörper
  • Applikationshinweise
    WB 1:500-1:2000, IHC 1:100-1:300, IF 1:100-1:300
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 mg/mL
    Buffer
    PBS with 0.02 % sodium azide and 50 % glycerol pH 7.4.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20°C. Avoid freeze / thaw cycles.
  • Target
    beta Catenin (CATNB) (Catenin, beta (CATNB))
    Andere Bezeichnung
    Catenin beta (CATNB Produkte)
    Synonyme
    Bfc antikoerper, Catnb antikoerper, Mesc antikoerper, CTNNB antikoerper, MRD19 antikoerper, armadillo antikoerper, ctnnb antikoerper, id:ibd2058 antikoerper, wu:fb73e10 antikoerper, wu:fi81c06 antikoerper, wu:fk25h01 antikoerper, beta-catenin antikoerper, ctnnb1 antikoerper, CHBCAT antikoerper, catenin (cadherin associated protein), beta 1 antikoerper, catenin beta 1 antikoerper, catenin (cadherin-associated protein), beta 1 antikoerper, catenin beta 1 L homeolog antikoerper, Ctnnb1 antikoerper, CTNNB1 antikoerper, ctnnb1 antikoerper, ctnnb1.L antikoerper
    Hintergrund
    Key dowstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes.Involved in the regulation of cell adhesion. The majority of beta-catenin is localized to the cell membrane and is part of E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton.
    Molekulargewicht
    92 kDa
    UniProt
    P35222
    Pathways
    Peptide Hormone Metabolism
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