CDK4 Antikörper
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- Target Alle CDK4 Antikörper anzeigen
- CDK4 (Cyclin-Dependent Kinase 4 (CDK4))
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Reaktivität
- Human, Maus, Ratte
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser CDK4 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), Immunohistochemistry (IHC)
- Produktmerkmale
- Polyclonal Antibody
- Aufreinigung
- Antigen Affinity Purification
- Immunogen
- Recombinant Human Cyclin-dependent kinase 4 protein
- Isotyp
- IgG
- Top Product
- Discover our top product CDK4 Primärantikörper
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- Applikationshinweise
- WB 1:1000-1:2000 IHC 1:100-1:300
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 1 mg/mL
- Buffer
- PBS with 0.05 % Proclin300 and 50 % glycerol, pH 7.4.
- Konservierungsmittel
- ProClin
- Vorsichtsmaßnahmen
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- Store at -20°C. Avoid freeze / thaw cycles.
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- Target
- CDK4 (Cyclin-Dependent Kinase 4 (CDK4))
- Andere Bezeichnung
- CDK4 (CDK4 Produkte)
- Hintergrund
- The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of this kinase is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a). This kinase was shown to be responsible for the phosphorylation of retinoblastoma gene product (Rb). Mutations in this gene as well as in its related proteins including D-type cyclins, p16(INK4a) and Rb were all found to be associated with tumorigenesis of a variety of cancers. Multiple polyadenylation sites of this gene have been reported.
- Molekulargewicht
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Observed_MW: 21 kDa
Calculated_MW: 34,21 kDa
- UniProt
- P11802
- Pathways
- Zellzyklus, Mitotic G1-G1/S Phases, Regulation of Cell Size
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