CTLA4 Antikörper (Extracellular Domain)

Produktnummer ABIN6992223

Dieses Anti-CTLA4-Antikörper ist ein Maus Monoklonal-Antikörper zur Detektion von CTLA4 in WB, ELISA, ICC, IF und IHC (p). Geeignet für Human.

Kurzübersicht für CTLA4 Antikörper (Extracellular Domain) (ABIN6992223)

Target: CTLA4 (Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA4))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser CTLA4 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Klon: 1E6

Produktdetails anti-CTLA4 Antikörper

Bindungsspezifität: Extracellular Domain

Aufreinigung: CTLA-4 Antibody is supplied as protein A purified IgG1.

Immunogen: CTLA-4 antibody was raised against the extracellular domain of human CTLA-4.

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: CTLA-4 antibody can be used for detection of CTLA-4 by Western blot at 0.125 - 0.25 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in human samples, Immunohistochemistry in human samples, Immunocytochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: CTLA-4 Antibody is supplied in PBS containing 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,4 °C

Informationen zur Lagerung: CTLA-4 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Details zu CTLA4

Target: CTLA4 (Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA4))

Andere Bezeichnung: CTLA4

Hintergrund: The cytotoxic T-lymphocyte-associated protein 4 (CTLA-4), also known as CD152, is a member of the immunoglobulin superfamily that is expressed by activated T cells and transmits an inhibitory signal to T cells (1,2). Both it and the homologous T-cell co-stimulatory protein CD28 bind to CD80 (B7-H1) and CD86 (B7-H2) on antigen-presenting cells (APCs) (3). Mutations in the CTLA-4 gene have been implicated in multiple autoimmune diseases (4). CTLA-4 also functions as an immune checkpoint protein, and anti- CTLA-4 antibodies have been successfully used in the treatment of cancer (5).

Molekulargewicht: Predicted: 25 kDa

Observed: 32 kDa

Gen-ID: 1493

NCBI Accession: NP_005205

UniProt: P16410

Pathways: Cancer Immune Checkpoints