UBD Antikörper (AA 80-130)

Produktnummer ABIN6992138

Der Kaninchen Polyklonal Anti-UBD-Antikörper wurde für WB, ELISA, IF und IHC (p) validiert. Er ist geeignet, UBD in Proben von Human zu detektieren.

Kurzübersicht für UBD Antikörper (AA 80-130) (ABIN6992138)

Target: UBD (Ubiquitin D (UBD))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser UBD Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-UBD Antikörper

Bindungsspezifität: AA 80-130

Spezifität: UBD antibody is human specific.

Aufreinigung: UBD antibody is affinity chromatography purified via peptide column.

Immunogen: UBD antibody was raised against a 16 amino acid peptide near the center of human UBD. The immunogen is located within amino acids 80 - 130 of UBD.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: UBD antibody can be used for detection of UBD by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in human samples, Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: UBD antibody is supplied in PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,4 °C

Informationen zur Lagerung: UBD antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Details zu UBD

Target: UBD (Ubiquitin D (UBD))

Andere Bezeichnung: UBD

Hintergrund: UBD, also designated ubiquitin D or diubiquitin, plays a role in antigen presentation, cytokine response and apoptosis. It is a 165 amino acid protein encoded in the major histocompatibility complex (MHC) that consists of two domains which share significant homology with ubiquitin (1,2). UBD is inducible by interferon gamma and TNF-alpha and regulates TNF-alpha-induced and LPS-mediated activation of the central mediator of innate immunity NF-kappa-B by promoting TNF-alpha-mediated proteasomal degradation of ubiquitinated-I-kappa-B-alpha (3). It may also regulate cell growth during dendritic cell or B cell activation and development (4,5).

Molekulargewicht: Predicted: 18 kDa

Observed: 17 kDa

Gen-ID: 10537

NCBI Accession: NP_006389

UniProt: O15205

Pathways: Ubiquitin Proteasome Pathway