NADPH Oxidase 4 Antikörper (N-Term)

Produktnummer ABIN6992045

Der Kaninchen Polyklonal Anti-NADPH Oxidase 4-Antikörper wurde für WB, ELISA, IF und IHC (p) validiert. Er ist geeignet, NADPH Oxidase 4 in Proben von Human, Ratte und Maus zu detektieren.

Kurzübersicht für NADPH Oxidase 4 Antikörper (N-Term) (ABIN6992045)

Target: NADPH Oxidase 4 (NOX4)

Reaktivität: Human, Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser NADPH Oxidase 4 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-NADPH Oxidase 4 Antikörper

Bindungsspezifität: AA 70-120, N-Term

Spezifität: NOX4 antibody is human, mouse, and rat reactive. At least four isoforms of NOX4 are known to exist. NOX4 is predicted to not cross-react with other NOX proteins.

Aufreinigung: NOX4 antibody is affinity chromatography purified via peptide column.

Immunogen: NOX4 antibody was raised against a 14 amino acid peptide near the amino terminus of human NOX4. The immunogen is located within amino acids 70 - 120 of NOX4.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: NOX4 antibody can be used for detection of NOX4 by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for Immunohistochemistry starting at 5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in human samples, Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: NOX4 antibody is supplied in PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,4 °C

Informationen zur Lagerung: NOX4 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Details zu NADPH Oxidase 4

Target: NADPH Oxidase 4 (NOX4)

Andere Bezeichnung: NOX4

Hintergrund: The NOX family of NAPDH oxidases is comprised of seven transmembrane proteins that oxidize intracellular NAPDH/NADH, causing electron transport across the membrane and the reduction of molecular oxygen to superoxide (1). NOX4 is is expressed in multiple tissues and catalyzes the reduction of molecular oxygen to various reactive oxygen species (ROS) (2,3). Unlike other NOX proteins, NOX4 does not require cytosolic subunits and thus is constitutively active (4). The function of NOX4 remains unclear as it plays both protective and deleterious roles in cellular metabolism.

Molekulargewicht: Predicted: 64 kDa

Observed: 68 kDa

Gen-ID: 50507

NCBI Accession: NP_058627

UniProt: Q9NPH5

Pathways: Carbohydrate Homeostasis, Smooth Muscle Cell Migration