KREMEN2 Antikörper (C-Term)

Produktnummer ABIN6991832

Der Kaninchen Polyklonal Anti-KREMEN2-Antikörper wurde für WB, ELISA und ICC validiert. Er ist geeignet, KREMEN2 in Proben von Human, Maus und Ratte zu detektieren.

Kurzübersicht für KREMEN2 Antikörper (C-Term) (ABIN6991832)

Target: KREMEN2 (Kringle Containing Transmembrane Protein 2 (KREMEN2))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser KREMEN2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunocytochemistry (ICC)

Produktdetails anti-KREMEN2 Antikörper

Bindungsspezifität: AA 390-440, C-Term

Spezifität: Multiple isoforms of KREMEN2 are known to exist. KREMEN2 antibody is predicted to not cross-react with other Kremen protein family members.

Aufreinigung: KREMEN2 Antibody is affinity chromatography purified via peptide column.

Immunogen: Anti-KREMEN2 antibody was raised against a peptide corresponding to 14 amino acids near the carboxy terminus of human KREMEN2. The immunogen is located within amino acids 390-440 of KREMEN2.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 1-2 μ,g/mL, ICC: 5 μ,g/mL.

Antibody validated: Western Blot in human, mouse and rat samples, Immunocytochemistry in human samples. All other applications and species not yet tested.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: KREMEN2 Antibody is supplied in PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,4 °C

Informationen zur Lagerung: KREMEN2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Details zu KREMEN2

Target: KREMEN2 (Kringle Containing Transmembrane Protein 2 (KREMEN2))

Andere Bezeichnung: KREMEN2

Hintergrund: KREMEN2 Antibody: Kremen (Kringle containing protein marking the eye and the nose) proteins are type I transmembrane proteins that contain extracellular kringle, WSC and CUB domains and an intracellular region without any conserved motifs. Kremens bind a subset of the secreted Dickkopf proteins (Dkk 1, 2, and 4) with high affinity to modulate the canonical Wnt signaling pathway that is transduced by the ternary receptor complex composed of Wnt, Frizzled, and the LDL receptor related protein 5/6 (LRP5/6) co-receptor. Recent experiments have shown that KREMEN2 is a regulator of bone remodeling and raise the possibility that antagonizing KREMEN2 might prove beneficial in patients with bone loss disorders.

Molekulargewicht: Predicted: 49kD

Observed: 49kD kDa

Gen-ID: 79412

NCBI Accession: NP_757384

UniProt: Q8NCW0

Pathways: WNT Signalweg