FOXA1 Antikörper (AA 270-320)

Produktnummer ABIN6991829

Der Kaninchen Polyklonal Anti-FOXA1-Antikörper wurde für WB und ELISA validiert. Er ist geeignet, FOXA1 in Proben von Human zu detektieren.

Kurzübersicht für FOXA1 Antikörper (AA 270-320) (ABIN6991829)

Target: FOXA1 (Forkhead Box A1 (FOXA1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser FOXA1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Produktdetails anti-FOXA1 Antikörper

Bindungsspezifität: AA 270-320

Spezifität: Multiple isoforms of FOXA1 exists as a result of alternative splicing event.

Aufreinigung: FOXA1 Antibody is affinity chromatography purified via peptide column.

Immunogen: Rabbit polyclonal FOXA1 antibody was raised against a 17 amino acid peptide near the center of human FOXA1. The immunogen is located within amino acids 270 - 320 of FOXA1.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: FOXA1 antibody can be used for detection of FOXA1 by Western blot at 1 - 2 μ,g/mL.

Antibody validated: Western Blot in human samples. All other applications and species not yet tested.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: FOXA1 Antibody is supplied in PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,4 °C

Informationen zur Lagerung: FOXA1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Details zu FOXA1

Target: FOXA1 (Forkhead Box A1 (FOXA1))

Andere Bezeichnung: FOXA1

Hintergrund: FOXA1 Antibody: FOXA1 is one of three members of the FOXA family, a subset of the forkhead family of transcription factors which play vital roles in development. It has also been implicated in the development of a number of other organs including the androgen and estrogen regulated tissues of the breast and prostate. FOXA1 modulates the transcriptional activity of nuclear hormone receptors and regulates apoptosis by inhibiting the expression of BCL-2. It is an essential protein for the transcriptional activity of both androgen receptor (AR) and estrogen receptor-α, (ER). FOXA1 plays a pivotal role from early stage cancer through to drug resistant and metastatic disease. FOXA1 is not only an attractive therapeutic target but could potentially function as a novel biomarker.

Molekulargewicht: 52 kDa

Gen-ID: 3169

NCBI Accession: NP_004487

UniProt: P55317

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Carbohydrate Homeostasis