CP110 Antikörper (C-Term)

Produktnummer ABIN6991685

Der Kaninchen Polyklonal Anti-CP110-Antikörper wurde für WB, ELISA, IHC (p) und IF validiert. Er ist geeignet, CP110 in Proben von Human, Maus und Ratte zu detektieren.

Kurzübersicht für CP110 Antikörper (C-Term) (ABIN6991685)

Target: CP110 (CCP110) (Centriolar Coiled Coil Protein 110kDa (CCP110))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CP110 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)

Produktdetails anti-CP110 Antikörper

Bindungsspezifität: C-Term

Spezifität: Two isoforms of CCP110 are known to exist, this antibody will only detect the longer isoform

Aufreinigung: CCP110 Antibody is affinity chromatography purified via peptide column.

Immunogen: CCP110 antibody was raised against a 17 amino acid synthetic peptide near the carboxy terminus of human CCP110. The immunogen is located within the last 50 amino acids of CCP110.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: CCP110 antibody can be used for detection of CCP110 by Western blot at 1 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 5 μ,g/mL. For immunofluorescence start at 5 μ,g/mL.

Antibody validated: Western Blot in human samples, Immunohistochemistry in rat samples and Immunofluorescence in rat samples. All other applications and species not yet tested.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: CCP110 Antibody is supplied in PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,4 °C

Informationen zur Lagerung: CCP110 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Details zu CP110

Target: CP110 (CCP110) (Centriolar Coiled Coil Protein 110kDa (CCP110))

Andere Bezeichnung: CCP110

Hintergrund: CCP110 Antibody: CCP110 is a centrosomal protein required for the centrosome to function as a microtubule organizing center and plays an essential role in centrosome duplication. It is a target of cyclin-dependent kinases (CDKs), disruption of CCP110 phosphorylation leads to unscheduled centrosome separation and polyploidy. CCP110 is also a target of SCF (Cyclin F) ubiquitin ligase complex, leading to its degradation, suggesting that this complex controls centrosome homeostasis and mitotic fidelity through CCP110 degradation. The centriolar kinesin Kif24 also interacts with CP110 and remodel microtubules and regulate ciliogenesis.

Molekulargewicht: Predicted: 110 kDa

Observed: 110 kDa

Gen-ID: 9738

NCBI Accession: NP_001185951

UniProt: O43303

Pathways: M Phase