PRICKLE1 Antikörper (C-Term)

Produktnummer ABIN6991606

Produktdetails anti-PRICKLE1 Antikörper

Target: PRICKLE1 (Prickle-Like Protein 1 (PRICKLE1))

Bindungsspezifität: C-Term

Reaktivität: Human, Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PRICKLE1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (IF)

Spezifität: Multiple isoforms of PRICKLE1 are known to exist. PRICKLE1 antibody is predicted to not cross-react with other PRICKLE protein family members.

Aufreinigung: PRICKLE1 Antibody is affinity chromatography purified via peptide column.

Immunogen: PRICKLE1 antibody was raised against a 19 amino acid synthetic peptide near the carboxy terminus of human PRICKLE1. The immunogen is located within the last 50 amino acids of PRICKLE1.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: PRICKLE1 antibody can be used for detection of PRICKLE1 by Western blot at 1 μ,g/mL. Antibody can also be used for immunofluorescence starting at 20 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: PRICKLE1 Antibody is supplied in PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,4 °C

Informationen zur Lagerung: PRICKLE1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Details zu PRICKLE1

Target: PRICKLE1 (Prickle-Like Protein 1 (PRICKLE1))

Andere Bezeichnung: PRICKLE1 (PRICKLE1 Produkte)

Synonyme: EPM1B antikoerper, RILP antikoerper, Rilp antikoerper, 1110058P22Rik antikoerper, AW215793 antikoerper, Prickle antikoerper, mpk1 antikoerper, XPk antikoerper, pk-B antikoerper, prickle antikoerper, prickle-B antikoerper, Prickle-b antikoerper, prickle planar cell polarity protein 1 antikoerper, prickle planar cell polarity protein 1 L homeolog antikoerper, prickle planar cell polarity protein 1 S homeolog antikoerper, PRICKLE1 antikoerper, Prickle1 antikoerper, prickle1.L antikoerper, prickle1.S antikoerper

Hintergrund: PRICKLE1 Antibody: PRICKLE1, also known as RILP or EPM1B, is a Disheveled-associated protein that serves as a nuclear translocation receptor for REST/NRSF and REST4 (1, 2). It contains three N-terminal LIM domains and three C-terminal nuclear localization signals. It localizes to the cytoplasm, as well as to the nuclear membrane and expressed at higher levels in placenta. PRICKLE1 is a negative regulator of the Wnt / beta-catenin signaling pathway and is a putative tumor suppressor in human HCCs. Defects in the gene encoding PRICKLE1 are associated with autosomal recessive progressive myoclonic epilepsy.

Molekulargewicht: Predicted: 46, 91 kDa

Observed: 52, 90 kDa

Gen-ID: 144165

NCBI Accession: NP_694571

UniProt: Q96MT3

Pathways: WNT Signalweg, Regulation of Muscle Cell Differentiation, Tube Formation, Skeletal Muscle Fiber Development, Protein targeting to Nucleus