NLRC3 Antikörper (AA 630-680)

Produktnummer ABIN6991397

Der Kaninchen Polyklonal Anti-NLRC3-Antikörper wurde für WB, ELISA und IF validiert. Er ist geeignet, NLRC3 in Proben von Human, Maus und Ratte zu detektieren.

Kurzübersicht für NLRC3 Antikörper (AA 630-680) (ABIN6991397)

Target: NLRC3 (NLR Family, CARD Domain Containing 3 (NLRC3))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser NLRC3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (IF)

Produktdetails anti-NLRC3 Antikörper

Bindungsspezifität: AA 630-680

Aufreinigung: NOD3 Antibody is affinity chromatography purified via peptide column.

Immunogen: NOD3 antibody was raised against an 18 amino acid synthetic peptide near the center of human NOD3. The immunogen is located within amino acids 630 - 680 of NOD3.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: NOD3 antibody can be used for detection of NOD3 by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for immunofluorescence starting at 20 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in mouse samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: NOD3 Antibody is supplied in PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,4 °C

Informationen zur Lagerung: NOD3 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Details zu NLRC3

Target: NLRC3 (NLR Family, CARD Domain Containing 3 (NLRC3))

Andere Bezeichnung: NOD3

Hintergrund: NOD3 Antibody: NOD3 is a member of the NOD (nucleotide-binding oligomerization domain) family, a group of proteins that are involved in innate immune defense. NOD3 also known as NLR family CARD containing 3 (NLRC3), is predominantly expressed in the immune system, particularly in T lymphocytes, and its expression is strongly down-regulated following stimulation of the T-cell receptor complex and CD28, suggesting that NOD3 plays a role in attenuating the activation of T cells. NOD3 inhibits NF-kappaB, AP-1 and NFAT transcriptional activation in Jurkat T cells downstream of CD3/CD28 stimulation or treatment with PMA/ionomycin and decreases IL-2 and CD25 mRNA induction in activated cells.

Gen-ID: 197358

UniProt: Q7RTR2