NLRC3 Antikörper (Center)

Produktnummer ABIN783697

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch NLRC3 in WB und EIA. Es zeigt Reaktivität gegenüber Proben von Maus, Human und Ratte.

Kurzübersicht für NLRC3 Antikörper (Center) (ABIN783697)

Target: NLRC3 (NLR Family, CARD Domain Containing 3 (NLRC3))

Reaktivität: Maus, Human, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser NLRC3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Enzyme Immunoassay (EIA)

Produktdetails anti-NLRC3 Antikörper

Bindungsspezifität: Center

Spezifität: This antibody detects NOD3 at Center.

Kreuzreaktivität (Details): Species reactivity (tested):Human, mouse, rat

Aufreinigung: Affinity chromatography purified via peptide column

Immunogen: 18 amino acid peptide near the center of human NOD3

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS containing 0.02 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at 2 - 8 °C for up to three months or (in aliquots) at -20 °C for longer.

Details zu NLRC3

Target: NLRC3 (NLR Family, CARD Domain Containing 3 (NLRC3))

Andere Bezeichnung: NOD3

Hintergrund: NOD3 is a member of the NOD (nucleotide-binding oligomerization domain) family, a group of proteins that are involved in innate immune defense. NOD3 also known as NLR family CARD containing 3 (NLRC3), is predominantly expressed in the immune system, particularly in T lymphocytes, and its expression is strongly down-regulated following stimulation of the T-cell receptor complex and CD28, suggesting that NOD3 plays a role in attenuating the activation of T cells. NOD3 inhibits NF-?B, AP-1 and NFAT transcriptional activation in Jurkat T cells downstream of CD3/CD28 stimulation or treatment with PMA/ionomycin and decreases IL-2 and CD25 mRNA induction in activated cells.Synonyms: CLR16.2, FLJ00348, NLRC3, NOD3

Gen-ID: 197358

NCBI Accession: NP_849172

UniProt: Q7RTR2