NLRC3 Antikörper

Produktnummer ABIN5564287

Produktdetails anti-NLRC3 Antikörper

Target: NLRC3 (NLR Family, CARD Domain Containing 3 (NLRC3))

Reaktivität: Maus

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser NLRC3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Spezifität: Detects overexpressed mouse NLRC3. Doest not detect human NLRC3. Although NLRC3 (mouse), mAb (Eowyn-1) is strong and specific (see figure), the endogenous protein has not been detected yet with this antibody (using NLRC3 KO versus WT immune cells). NLRC3 protein is probably expressed at very low levels or its translation / stability is triggered by stimuli still to be discovered .

Kreuzreaktivität: Maus

Reinheit: >95 % (SDS-PAGE)

Immunogen: Recombinant mouse NLRC3 (card domain).

Klon: Eowyn-1

Isotyp: IgG1

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: In PBS containing 10 % glycerol and 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Short Term Storage: +4°C
Long Term Storage: -20°C
Stable for at least 1 year after receipt when stored at -20°C.

Haltbarkeit: 12 months

Details zu NLRC3

Target: NLRC3 (NLR Family, CARD Domain Containing 3 (NLRC3))

Andere Bezeichnung: NLRC3 (NLRC3 Produkte)

Synonyme: NLRC3 antikoerper, nod3 antikoerper, NLR-A3 antikoerper, NOD3 antikoerper, CLR16.2 antikoerper, D230007K08Rik antikoerper, mFLJ00348 antikoerper, Nlrc3-ps1 antikoerper, RGD1304902 antikoerper, NLR family CARD domain containing 3 antikoerper, NLR family, CARD domain containing 3 antikoerper, NLRC3 antikoerper, nlrc3 antikoerper, Nlrc3 antikoerper

Hintergrund: The novel nucleotide oligomerization domain (NOD)-like receptor (NLR) with a caspase activation and recruitment domain (CARD) 3 (NLRC3) protein belongs to the NLR family of cytosolic pathogen recognition receptors. NLRC3 has the characteristic NOD and leucine-rich repeat configuration with a less well defined CARD. NLRC3 is expressed in T lymphocytes and may be involved in suppression of T cell activation. NLRC3 is a cytoplasmic protein that negatively regulates pro-IL-1beta maturation and inhibits toll-like receptor (TLR)-dependent activation of the transcription factor NF-kappaB. NLRC3 interacts with the TLR signaling adaptor TRAF6 to attenuate Lys63 (K63)-linked ubiquitination of TRAF6 and activation of NF-kappaB. NLRC3 also reduces STING-dependent innate immune activation in response to cytosolic DNA, cyclic di-GMP (c-di-GMP) and DNA viruses. NLRC3 associated with both STING and TBK1, impedes STING-TBK1 interaction and downstream type I interferon production.

UniProt: Q5DU56