SIRT4 Antikörper (N-Term)

Produktnummer ABIN6991345

Dieses Huhn Polyklonal-Antikörper erkennt spezifisch SIRT4 in WB und ELISA. Er zeigt eine Reaktivität gegenüber Human, Maus und Ratte.

Kurzübersicht für SIRT4 Antikörper (N-Term) (ABIN6991345)

Target: SIRT4 (Sirtuin 4 (SIRT4))

Reaktivität: Human, Maus, Ratte

Wirt: Huhn

Klonalität: Polyklonal

Konjugat: Dieser SIRT4 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Produktdetails anti-SIRT4 Antikörper

Bindungsspezifität: AA 80-130, N-Term

Aufreinigung: SIRT4 Antibody is affinity chromatography purified via peptide column.

Immunogen: SIRT4 antibody was raised against a 17 amino acid synthetic peptide near the amino terminus of human SIRT4. The immunogen is located within amino acids 80 - 130 of SIRT4.

Isotyp: IgY

Anwendungsinformationen

Applikationshinweise: SIRT4 antibody can be used for detection of SIRT4 by Western blot at 1 - 2 μ,g/mL.

Antibody validated: Western Blot in human and mouse samples. All other applications and species not yet tested.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: SIRT4 Antibody is supplied in PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,4 °C

Informationen zur Lagerung: SIRT4 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Details zu SIRT4

Target: SIRT4 (Sirtuin 4 (SIRT4))

Andere Bezeichnung: SIRT4

Hintergrund: SIRT4 Antibody: The Silent Information Regulator (SIR2) family of genes are highly conserved from prokaryotes to eukaryotes and have important functions in the regulation of metabolism, growth and differentiation, inflammation, cellular survival, as well as in senescence and lifespan extension. Sirtuins, including SIRT1-7, are human homologs of yeast Sir2p. Sirtuins are NAD+-dependent histone/protein deacetylases (HDAC) which regulate cellular metabolism, e.g. energy metabolism, and thereby are associated with aging and several age-related diseases. SIRT4 localizes to mitochondria, inhibits glutamate dehydrogenase, and is thought to be involved in the regulation of insulin secretion.

Molekulargewicht: Predicted: 37 kDa

Observed: 40 kDa

Gen-ID: 23409

UniProt: Q9Y6E7

Pathways: Negative Regulation of Hormone Secretion