UCMA Antikörper (C-Term)

Produktnummer ABIN6991131

Dieses Anti-UCMA-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von UCMA in WB und ELISA. Geeignet für Human und Maus.

Kurzübersicht für UCMA Antikörper (C-Term) (ABIN6991131)

Target: UCMA (Upper Zone of Growth Plate and Cartilage Matrix Associated (UCMA))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser UCMA Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Produktdetails anti-UCMA Antikörper

Bindungsspezifität: C-Term

Aufreinigung: UCMA Antibody is affinity chromatography purified via peptide column.

Immunogen: UCMA antibody was raised against a 16 amino acid synthetic peptide near the carboxy terminus of human UCMA. The immunogen is located within the last 50 amino acids of UCMA.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: UCMA antibody can be used for detection of UCMA by Western blot at 2.5 - 5 μ,g/mL.

Antibody validated: Western Blot in human samples. All other applications and species not yet tested.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: UCMA Antibody is supplied in PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,4 °C

Informationen zur Lagerung: UCMA antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Details zu UCMA

Target: UCMA (Upper Zone of Growth Plate and Cartilage Matrix Associated (UCMA))

Andere Bezeichnung: UCMA

Hintergrund: UCMA Antibody: UCMA is a secreted cartilage-specific protein that was discovered in a screen for differentially expressed genes in retinoic acid-treated mouse chondrocytes. It was also identified in a human chondrocyte EST screen for candidate genes of skeletal dysplasias. UCMA expression is thought to parallel that of collagen II with its expression decreasing with maturation chrondrocytes mature. UCMA is processed by a furin-like protease into two fragments, an amino-terminal fragment and a carboxy-terminal fragment (UCMA-C). Application of recombinant UCMA-C to primary osteoblasts, mesenchymal stem cells, and MC3T3-E1 pre-osteoblasts interferes with their osteogenic differentiation, but does not affect expression of chondrocyte-specific genes or chondrocyte proliferation, suggesting that UCMA may be involved in the negative control of osteogenic differentiation of osteochondrogenic precursor cells. At least two isoforms of UCMA are known to exist.

Molekulargewicht: Predicted: 15 kDa

Observed: 19 kDa

Gen-ID: 221044

NCBI Accession: NP_660357

UniProt: Q8WVF2