UCMA Antikörper (AA 21-120)

Produktnummer ABIN1713925

Produktdetails anti-UCMA Antikörper

Target: UCMA (Upper Zone of Growth Plate and Cartilage Matrix Associated (UCMA))

Bindungsspezifität: AA 21-120

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser UCMA Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Homologie: Human,Mouse,Rat

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human UCMA

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Details zu UCMA

Target: UCMA (Upper Zone of Growth Plate and Cartilage Matrix Associated (UCMA))

Andere Bezeichnung: UCMA (UCMA Produkte)

Synonyme: BN antikoerper, GRP-10 antikoerper, preproGRP antikoerper, proGRP antikoerper, grp antikoerper, GRP2 antikoerper, ucma antikoerper, zgc:162317 antikoerper, C10orf49 antikoerper, GRP antikoerper, RGD1308977 antikoerper, 1110017I16Rik antikoerper, AW121955 antikoerper, Grp antikoerper, GRP1 antikoerper, zgc:85838 antikoerper, gastrin releasing peptide antikoerper, upper zone of growth plate and cartilage matrix associated antikoerper, upper zone of growth plate and cartilage matrix associated L homeolog antikoerper, upper zone of growth plate and cartilage matrix associated a antikoerper, upper zone of growth plate and cartilage matrix associated b antikoerper, GRP antikoerper, UCMA antikoerper, ucma.L antikoerper, ucmaa antikoerper, ucma antikoerper, Ucma antikoerper, ucmab antikoerper

Hintergrund:

Synonyms: C10orf49, Gla rich protein, Gla-rich protein, Grp, GRP, OTTMUSP00000011599, RP23-272I15.1, UCMA, Ucma-C, UCMA_HUMAN, Unique cartilage matrix associated protein, Unique cartilage matrix-associated protein C-terminal fragment, Upper zone of growth plate and cartilage matrix associated.

Background: UCMA is a 138 amino acid secreted protein that is highly expressed in resting chrondrocytes in developing long bones and is thought to function in the early phase of chrondrocyte differentiation. A furin-like protease processes UCMA into an N-terminal 37 amino acid peptide and a C-terminal 74 amino acid peptide, which is referred to as Unique cartilage matrix-associated protein C-terminal fragment (Ucma-C). Introduction of recombinant Ucma-C interferes with osteogenic differentiation of mesenchymal stem cells, MC3T3-E1 preosteoblasts and primary osteoblasts. This suggests that Ucma may be involved in the negative regulation of osteogenic differentiation of osteochondrogenic precursor cells at the cartilage-bone interface and in peripheral zones of fetal cartilage.

Gen-ID: 221044