STIM1 Antikörper (C-Term)

Produktnummer ABIN6990744

Der Kaninchen Polyklonal anti-STIM1 Antikörper (ABIN6990744) detektiert spezifisch STIM1 in WB, ELISA, IF und IHC (p). Dieser Antikörper reagiert spezifisch mit Proben aus Human, Ratte und Maus.

Kurzübersicht für STIM1 Antikörper (C-Term) (ABIN6990744)

Target: STIM1 (Stromal Interaction Molecule 1 (STIM1))

Reaktivität: Human, Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser STIM1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-STIM1 Antikörper

Bindungsspezifität: C-Term

Spezifität: At least two isoforms of STIM1 are known to exist, this antibody will detect only the larger form. This STIM1 antibody is predicted to have no cross-reactivity to STIM2.

Aufreinigung: STIM1 Antibody is affinity chromatography purified via peptide column.

Immunogen: STIM1 antibody was raised against a 24 amino acid synthetic peptide from near the carboxy terminus of human STIM1. The immunogen is located within the last 50 amino acids of STIM1.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: STIM1 antibody can be used for detection of STIM1 by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μ,g/mL.

Antibody validated: Western Blot in mouse samples, Immunohistochemistry in human and mouse samples and Immunofluorescence in human and mouse samples. All other applications and species not yet tested.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: STIM1 Antibody is supplied in PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,4 °C

Informationen zur Lagerung: STIM1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Details zu STIM1

Target: STIM1 (Stromal Interaction Molecule 1 (STIM1))

Andere Bezeichnung: STIM1

Hintergrund: STIM1 Antibody: In T lymphocytes, the sole pathway for Ca²⁺ entry following antigen-receptor binding is through store-operated Ca²⁺-release-activated Ca²⁺ (CRAC) channels. These channels are made up of the pore-forming subunit ORAI1 and the stromal interaction molecule 1 (STIM1), a protein that functions as a Ca²⁺ sensor and activates the CRAC channels, migrating to the plasma membrane from endoplasmic reticulum (ER)-like sites which act as the Ca²⁺ store. A related molecule, STIM2, acts to inhibit the STIM1-mediated store-operated Ca²⁺ entry, and can form complexes with STIM1, suggesting they may play a coordinated role in controlling Ca²⁺ entry.

Molekulargewicht: Predicted: 59, 75, 87 kDa

Observed: 88 kDa

Gen-ID: 6786

NCBI Accession: NP_003147

UniProt: Q13586

Pathways: T-Zell Rezeptor Signalweg, BCR Signaling