TLR6 Antikörper (N-Term)

Produktnummer ABIN6990589

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch TLR6 in WB, ELISA und ICC. Er zeigt eine Reaktivität gegenüber Human und Maus.

Kurzübersicht für TLR6 Antikörper (N-Term) (ABIN6990589)

Target: TLR6 (Toll-Like Receptor 6 (TLR6))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TLR6 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunocytochemistry (ICC)

Produktdetails anti-TLR6 Antikörper

Bindungsspezifität: AA 160-210, N-Term

Spezifität: This TLR6 antibody is predicted to have no cross-reactivity to other members of the TLR protein family.

Aufreinigung: TLR6 Antibody is affinity chromatography purified via peptide column.

Immunogen: TLR6 antibody was raised against a peptide corresponding to 15 amino acids near the amino terminus of human TLR6. The immunogen is located within amino acids 160 - 210 of TLR6.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: TLR6 antibody can be used for detection of TLR6 by Western blot at 1 μ,g/mL. Antibody can also be used for immunocytochemistry starting at 10 μ,g/mL.

Antibody validated: Western Blot in human samples and Immunocytochemistry in human samples. All other applications and species not yet tested.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: TLR6 Antibody is supplied in PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,4 °C

Informationen zur Lagerung: TLR6 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Details zu TLR6

Target: TLR6 (Toll-Like Receptor 6 (TLR6))

Andere Bezeichnung: TLR6

Hintergrund: TLR6 Antibody: Toll-like receptors (TLRs) are evolutionarily conserved pattern-recognition molecules resembling the toll proteins that mediate antimicrobial responses in Drosophila. These proteins recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. The TLRs act through adaptor molecules such as MyD88 and TIRAP to activate various kinases and transcription factors so the organism can respond to potential infection. TLR6 was first identified as a close homolog of TLR1, sharing 69 % sequence identify. Like TLR1, TLR6 can form heterodimers with TLR2, and these TLR6:TLR2 dimers coordinate macrophage activation by Gram-positive bacteria and the yeast cell wall particle zymosan. Activation of these complexes not only initiates pro-inflammatory cascades, but also can lead to apoptotic responses.

Molekulargewicht: Observed: 91 kDa

Gen-ID: 10333

NCBI Accession: NP_006059

UniProt: Q9Y2C9

Pathways: TLR Signalweg, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Toll-Like Receptors Cascades