MCL-1 Antikörper (AA 110-160)

Produktnummer ABIN6990528

Der Kaninchen Polyklonal anti-MCL-1 Antikörper (ABIN6990528) detektiert spezifisch MCL-1 in WB, ELISA und ICC. Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für MCL-1 Antikörper (AA 110-160) (ABIN6990528)

Target: MCL-1 (MCL1) (Induced Myeloid Leukemia Cell Differentiation Protein Mcl-1 (MCL1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MCL-1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunocytochemistry (ICC)

Produktdetails anti-MCL-1 Antikörper

Bindungsspezifität: AA 110-160

Spezifität: Detects isoforms Mcl-1L and Mcl-1S

Aufreinigung: Mcl-1 Antibody is Ion exchange chromatography purified.

Immunogen: Mcl-1 antibody was raised against a peptide corresponding to 16 amino acids near the center of human Mcl-1. The immunogen is located within amino acids 110 - 160 of Mcl-1.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Mcl-1 antibody can be used for detection of isoforms Mcl-1L and Mcl-1S by Western blot at 0.5 to 2 μ,g/mL. Antibody can also be used for immunocytochemistry starting at 10 μ,g/mL.

Antibody validated: Western Blot in human samples and Immunocytochemistry in human samples. All other applications and species not yet tested.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Mcl-1 Antibody is supplied in PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,4 °C

Informationen zur Lagerung: Mcl-1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Details zu MCL-1

Target: MCL-1 (MCL1) (Induced Myeloid Leukemia Cell Differentiation Protein Mcl-1 (MCL1))

Andere Bezeichnung: Mcl-1

Hintergrund: Mcl-1 Antibody: Myeloid cell leukimia-1 (Mcl-1) is a member of the Bcl-2 family of proteins that can act to promote cell survival. While the mechanism by which Mcl-1 inhibits apoptosis is not known, it is thought that it may heterodimerize and neutralize pro-apoptotic members of the Bcl-2 family such as Bim or Bak. Mcl-1 was originally identified in differentiating myeloid cells, but has since been shown to be expressed in multiple cell types. Mcl-1 is essential for embryogenesis and for the development and maintenance of B and T lymphocytes in animals. Mcl-1 exists as at least three distinct isoforms designated Mcl-1L, Mcl-1S and Mcl-1ES. In marked contrast to the larger isoform of Mcl-1, overexpression of Mcl-1S promotes cell death.

Gen-ID: 4170

NCBI Accession: NP_068779

UniProt: Q07820

Pathways: MAPK Signalweg