ADAM17 Antikörper (C-Term)

Produktnummer ABIN6990406

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch ADAM17 in WB, ELISA, ICC und IF. Es zeigt Reaktivität gegenüber Proben von Human und Ratte.

Kurzübersicht für ADAM17 Antikörper (C-Term) (ABIN6990406)

Target: ADAM17 (ADAM Metallopeptidase Domain 17 (ADAM17))

Reaktivität: Human, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ADAM17 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF)

Produktdetails anti-ADAM17 Antikörper

Bindungsspezifität: C-Term

Spezifität: 80 to 130 kDa bands can be detected, which may represent mature protein, precursor, and glycosylated TACE.

Aufreinigung: TACE Antibody is affinity chromatography purified via peptide column.

Immunogen: Anti-TACE antibody was raised against a peptide corresponding to 17 amino acids near the carboxy terminus of human TACE. The immunogen is located within the last 50 amino acids of TACE.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 0.25-2 μ,g/mL, ICC: 10 μ,g/mL, IF: 10 μ,g/mL.

Antibody validated: Western Blot in human and rat samples, Immunocytochemistry in human samples, and Immunofluorescence in human and rat samples. All other applications and species not yet tested.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: TACE Antibody is supplied in PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,4 °C

Informationen zur Lagerung: TACE antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Details zu ADAM17

Target: ADAM17 (ADAM Metallopeptidase Domain 17 (ADAM17))

Andere Bezeichnung: TACE

Hintergrund: TACE Antibody: Tumor-necrosis factor-alpha is a proinflammatory cytokine and contributes to a variety of inflammatory disease responses and programmed cell death. TNF-α, is synthesized as a 26K type II membrane-bound precursor that is cleaved by a convertase to generate secreted 17K mature TNF-α,. TNF-α, converting enzyme (TACE) protein was recently purified and the human and mouse TACE cDNAs were cloned by several groups separately. TACE is a membrane-bound metalloprotease-disintegrin in the family of mammalian ADAM (for a disintegrin and metalloprotease). TACE also processes other cell surface proteins, including TNF receptor, TGFalpha, the L-selectin adhesion molecule, and alpha-cleavage of amyloid protein precursor (APP). TACE mRNA is expressed in a variety of human and murine tissues. TACE was selected as one of the few targets in cytokine activation by the Eighth International Conference of the Inflammation Research Association.

Molekulargewicht: Predicted: 93kD

Observed: 93-125kD (Post-modification: 9 N-linked glycosylation) kDa

Gen-ID: 6868

NCBI Accession: NP_003174

UniProt: P78536

Pathways: Notch Signalweg, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Response to Growth Hormone Stimulus