TBK1 Antikörper (C-Term)

Produktnummer ABIN6990357

Der Kaninchen Polyklonal anti-TBK1 Antikörper (ABIN6990357) detektiert spezifisch TBK1 in WB, ELISA und ICC. Dieser Antikörper reagiert spezifisch mit Proben aus Human und Maus.

Kurzübersicht für TBK1 Antikörper (C-Term) (ABIN6990357)

Target: TBK1 (TANK-Binding Kinase 1 (TBK1))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TBK1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunocytochemistry (ICC)

Produktdetails anti-TBK1 Antikörper

Bindungsspezifität: C-Term

Spezifität: No cross response to IKKa, IKKb, IKKy, or IKKe.

Aufreinigung: NAK Antibody is affinity chromatography purified via peptide column.

Immunogen: NAK antibody was raised against a synthetic peptide corresponding to 17 amino acids form near the carboxy terminus of human NAK/TBK1. The immunogen is located within the last 50 amino acids of NAK.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: NAK antibody can be used for detection of NAK/TBK1 by Western blot. An 84 kDa band should be detected. Antibody can also be used for immunocytochemistry starting at 10 μ,g/mL.

Antibody validated: Immunocytochemistry in human samples. All other applications and species not yet tested.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: NAK Antibody is supplied in PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,4 °C

Informationen zur Lagerung: NAK antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Details zu TBK1

Target: TBK1 (TANK-Binding Kinase 1 (TBK1))

Andere Bezeichnung: NAK

Hintergrund: NAK Antibody: Nuclear factor kappa B (NF-κ,B) is a ubiquitous transcription factor and an essential mediator of gene expression during activation of immune and inflammatory responses. NF-κ,B mediates the expression of a great variety of genes in response to extracellular stimuli. NF-κ,B is associated with Iκ,B proteins in the cell cytoplasm, which inhibit NF-κ,B activity. Phosphorylation of I-kappaB by Iκ,B kinase (IKK) complex leads to degradation of I-kappaB and activation of NF-κ,B. The IKK complex contains IKKα, IKKβ, and IKKγ,. A novel IKK related kinase was recently identified and designated TBK1 (TANK-binding kinase 1), NAK (NF-κ,B-activating kinase), and T2K. NAK/TBK1 activates IKKβ, through direct phosphorylation. NAK/TBK1 is activated by growth factors and PMA and mediates IKK and NF-κ,B activation in response to growth factors. NAK/TBK1 functions upstream of NIK and the IKK complex. NAK/TBK1 is also critical in protecting embryonic liver from apoptosis.

Molekulargewicht: 84 kDa

Gen-ID: 29110

NCBI Accession: NP_037386

UniProt: Q9UHD2

Pathways: TLR Signalweg, Activation of Innate immune Response, Hepatitis C, Toll-Like Receptors Cascades, SARS-CoV-2 Protein Interaktom