INPP5D Antikörper (pTyr1020)
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- Target Alle INPP5D Antikörper anzeigen
- INPP5D (Inositol Polyphosphate-5-Phosphatase, 145kDa (INPP5D))
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Bindungsspezifität
- pTyr1020
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Reaktivität
- Human
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Wirt
- Kaninchen
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Klonalität
- Monoklonal
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Konjugat
- Dieser INPP5D Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), Immunoprecipitation (IP), Immunofluorescence (Cultured Cells) (IF (cc))
- Kreuzreaktivität
- Human
- Aufreinigung
- Purified by Protein A.
- Immunogen
- Synthetic phospho-Peptide corresponding to residues surrounding Tyr1020 of human SHIP.
- Klon
- 1H11
- Isotyp
- IgG
- Top Product
- Discover our top product INPP5D Primärantikörper
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- Applikationshinweise
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WB 1:300-5000
IF(ICC) 1:50-200
IP(1-2 μg) - Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 1 μg/μL
- Buffer
- Aqueous buffered solution containing 1xTBS ( pH 7.4), 1 % BSA, 40 %Glycerol and 0.05 % Sodium Azide.
- Konservierungsmittel
- ProClin
- Vorsichtsmaßnahmen
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- Store at -20°C for 12 months.
- Haltbarkeit
- 12 months
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- Target
- INPP5D (Inositol Polyphosphate-5-Phosphatase, 145kDa (INPP5D))
- Andere Bezeichnung
- SHIP (INPP5D Produkte)
- Synonyme
- INPP5D antikoerper, 256.t00004 antikoerper, 13.t00027 antikoerper, ship antikoerper, ship1 antikoerper, AI323613 antikoerper, SHIP antikoerper, SHIP-1 antikoerper, SHIP1 antikoerper, s-SHIP antikoerper, SIP-145 antikoerper, hp51CN antikoerper, inositol polyphosphate-5-phosphatase D antikoerper, phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 antikoerper, inositol polyphosphate 5-phosphatase antikoerper, inositol polyphosphate-5-phosphatase D L homeolog antikoerper, INPP5D antikoerper, LOC100446045 antikoerper, inpp5d antikoerper, EHI_159880 antikoerper, EHI_153490 antikoerper, inpp5d.L antikoerper, LOC100380693 antikoerper, Inpp5d antikoerper
- Hintergrund
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Synonyms: Inositol polyphosphate 5 phosphatase of 145 kDa antibody, 4 antibody, 5-trisphosphate 5-phosphatase 1 antibody, hp51CN antibody, Inositol polyphosphate 5 phosphatase 145 kDa antibody, Inositol polyphosphate 5 phosphatase antibody, Inositol polyphosphate-5-phosphatase of 145 kDa antibody, INPP5D antibody, MGC104855 antibody, MGC142140 antibody, MGC142142 antibody, p150Ship antibody, Phosphatidylinositol 3,4,5 trisphosphate 5 phosphatase 1 antibody, Phosphatidylinositol-3 antibody, SH2 containing inositol phosphatase isoform b antibody, SH2 domain containing inositol 5' phosphatase 1 antibody, SH2 domain containing inositol phosphatase 1 antibody, SH2 domain-containing inositol phosphatase 1 antibody, SH2 domain-containing inositol-5'-phosphatase 1 antibody, SHIP-1 antibody, SHIP1 antibody, SHIP1_HUMAN antibody, Signaling inositol polyphosphate 5 phosphatase SIP 145 antibody, SIP-145 antibody, SIP145 antibody
Background: SHIP1 is a member of the inositol polyphosphate-5-phosphatase (INPP5) family and contains an N-terminal SH2 domain, an inositol phosphatase domain, and two C-terminal protein interaction domains. Expression of this protein is restricted to hematopoietic cells where its movement from the cytosol to the plasma membrane is mediated by tyrosine phosphorylation in response to multiple cytokine and B and T cell receptor activation. At the plasma membrane, the protein hydrolyzes the 5' phosphate from phosphatidylinositol (3,4,5)-trisphosphate and inositol-1,3,4,5-tetrakisphosphate, thereby affecting multiple signaling pathways. Overall the protein functions as a negative regulator of myeliod cell proliferation and survival.
- Gen-ID
- 3635
- UniProt
- Q92835
- Pathways
- T-Zell Rezeptor Signalweg, BCR Signaling, Warburg Effekt
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