Telefon:
+49 (0)241 95 163 153
Fax:
+49 (0)241 95 163 155
E-Mail:
orders@antikoerper-online.de

LIG4 Antikörper

This anti-LIG4 antibody (ABIN6989825) is a Rabbit Polyclonal antibody detecting LIG4 in WB, IF. Suitable for Human, Mouse.
Produktnummer ABIN6989825

Kurzübersicht für LIG4 Antikörper (ABIN6989825)

Target

Alle LIG4 Antikörper anzeigen
LIG4 (Ligase IV, DNA, ATP-Dependent (LIG4))

Reaktivität

  • 63
  • 11
  • 10
  • 3
  • 3
  • 2
  • 1
  • 1
  • 1
  • 1
Human, Maus

Wirt

  • 62
  • 2
Kaninchen

Klonalität

  • 52
  • 12
Polyklonal

Konjugat

  • 30
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser LIG4 Antikörper ist unkonjugiert

Applikation

  • 37
  • 16
  • 15
  • 13
  • 13
  • 10
  • 9
  • 7
  • 3
  • 1
  • 1
Western Blotting (WB), Immunofluorescence (IF)
  • Kreuzreaktivität

    Human, Maus

    Aufreinigung

    Purified by Protein A.

    Immunogen

    Recombinant fusion protein containing a sequence corresponding to amino acids 612-911 of human LIG4 (NP_002303.2).

    Isotyp

    IgG
  • Applikationshinweise

    WB 1:300-5000
    IF()

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Konzentration

    1 μg/μL

    Buffer

    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

    Konservierungsmittel

    ProClin

    Vorsichtsmaßnahmen

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

    Lagerung

    -20 °C

    Informationen zur Lagerung

    Store at -20°C for 12 months.

    Haltbarkeit

    12 months
  • Target

    LIG4 (Ligase IV, DNA, ATP-Dependent (LIG4))

    Andere Bezeichnung

    LIG4

    Hintergrund

    Synonyms: LIG4,LIG4S

    Background: The protein encoded by this gene is a DNA ligase that joins single-strand breaks in a double-stranded polydeoxynucleotide in an ATP-dependent reaction. This protein is essential for V(D)J recombination and DNA double-strand break (DSB) repair through nonhomologous end joining (NHEJ). This protein forms a complex with the X-ray repair cross complementing protein 4 (XRCC4), and further interacts with the DNA-dependent protein kinase (DNA-PK). Both XRCC4 and DNA-PK are known to be required for NHEJ. The crystal structure of the complex formed by this protein and XRCC4 has been resolved. Defects in this gene are the cause of LIG4 syndrome. Alternatively spliced transcript variants encoding the same protein have been observed.

    Gen-ID

    3981

    UniProt

    P49917

    Pathways

    DNA Reparatur, Production of Molecular Mediator of Immune Response
Sie sind hier:
Chat with us!