EGLN1 Antikörper
Kurzübersicht für EGLN1 Antikörper (ABIN6989779)
Target
Alle EGLN1 Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
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Verwendungszweck
- EGLN1 Polyclonal Antibody
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Kreuzreaktivität
- Human, Maus, Ratte
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Aufreinigung
- Purified by Protein A.
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Immunogen
- Recombinant fusion protein containing a sequence corresponding to amino acids 1-426 of human EGLN1 (NP_071334.1).
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Isotyp
- IgG
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Applikationshinweise
- WB(1:300-5000), IHC-P(1:200-400), IF(ICC)(1:50-200), IHC(1:50-200), IF()
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Liquid
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Konzentration
- 1 μg/μL
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Buffer
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
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Konservierungsmittel
- ProClin
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Vorsichtsmaßnahmen
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Lagerung
- -20 °C
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Informationen zur Lagerung
- Store at -20°C for 12 months.
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Haltbarkeit
- 12 months
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- EGLN1 (Egl-9 Family Hypoxia Inducible Factor 1 (EGLN1))
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Andere Bezeichnung
- EGLN1
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Hintergrund
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Synonyms: EGLN1,C1orf12,ECYT3,HALAH,HIF-PH2,HIFPH2,HPH-2,HPH2,PHD2,SM20,ZMYND6
Background: The protein encoded by this gene catalyzes the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. HIF is a transcriptional complex that plays a central role in mammalian oxygen homeostasis. This protein functions as a cellular oxygen sensor, and under normal oxygen concentration, modification by prolyl hydroxylation is a key regulatory event that targets HIF subunits for proteasomal destruction via the von Hippel-Lindau ubiquitylation complex. Mutations in this gene are associated with erythrocytosis familial type 3 (ECYT3).
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Gen-ID
- 54583
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UniProt
- Q9GZT9
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Pathways
- cAMP Metabolic Process, Warburg Effekt
Target
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