CDK9 Antikörper (N-Term)

Produktnummer ABIN6971511

Produktdetails anti-CDK9 Antikörper

Target: CDK9 (Cyclin-Dependent Kinase 9 (CDK9))

Bindungsspezifität: N-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CDK9 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktmerkmale: CDK9 (cyclin-dependent kinase 9) is a protein kinase involved in the regulation of transcription. Member of the cyclin-dependent kinase pair (CDK9/cyclin-T) complex, also called positive transcription elongation factor b (P-TEFb), which facilitates the transition from abortive to productive elongation by phosphorylating the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAP II) POLR2A, SUPT5H and RDBP. This complex is inactive when in the 7SK snRNP complex form. Phosphorylates EP300, MYOD1, RPB1/POLR2A and AR, and the negative elongation factors DSIF and NELF. Regulates cytokine inducible transcription networks by facilitating promoter recognition of target transcription factors (e.g. TNF-inducible RELA/p65 activation and IL-6-inducible STAT3 signaling). Promotes RNA synthesis in genetic programs for cell growth, differentiation and viral pathogenesis. P-TEFb is also involved in cotranscriptional histone modification, mRNA processing and mRNA export. Modulates a complex network of chromatin modifications including histone H2B monoubiquitination (H2Bub1), H3 lysine 4 trimethylation (H3K4me3) and H3K36me3, integrates phosphorylation during transcription with chromatin modifications to control co-transcriptional histone mRNA processing. CDK9 antibody (pAb) was raised in a Rabbit host. It has been validated for use in Western blot, it has been shown to react with Human samples.

Aufreinigung: Affinity Purified

Immunogen: This antibody was raised against a peptide within the N-terminal region of human CDK9.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: Purified IgG in 70 mM Tris ( pH 8), 105 mM NaCl, 31 mM glycine, 0.07 mM EDTA, 30 % glycerol and 0.035 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.

Details zu CDK9

Target: CDK9 (Cyclin-Dependent Kinase 9 (CDK9))

Andere Bezeichnung: CDK9 (CDK9 Produkte)

Synonyme: C-2k antikoerper, CDC2L4 antikoerper, CTK1 antikoerper, PITALRE antikoerper, TAK antikoerper, wu:fb22e09 antikoerper, wu:fc06c02 antikoerper, c-2k antikoerper, cdc2l4 antikoerper, cdk9 antikoerper, ctk1 antikoerper, pitalre antikoerper, tak antikoerper, CDK9 antikoerper, CG5179 antikoerper, Dmel\\CG5179 antikoerper, P-TEF antikoerper, P-TEFb antikoerper, PTefb antikoerper, cyclin dependent kinase 9 antikoerper, cyclin-dependent kinase 9 (CDC2-related kinase) antikoerper, cyclin-dependent kinase 9 L homeolog antikoerper, cyclin-dependent kinase 9 antikoerper, Cyclin-dependent kinase 9 antikoerper, cyclin-dependent kinase 9 S homeolog antikoerper, CDK9 antikoerper, cdk9 antikoerper, cdk9.L antikoerper, Cdk9 antikoerper, cdk9.S antikoerper

Molekulargewicht: 44 kDa

NCBI Accession: NP_001252

Pathways: Zellzyklus