beta Catenin Antikörper (N-Term)
Kurzübersicht für beta Catenin Antikörper (N-Term) (ABIN6971443)
Target
Alle beta Catenin (CATNB) Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
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Bindungsspezifität
- N-Term
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Produktmerkmale
- beta-Catenin is a key downstream component of the canonical Wnt signaling pathway, plays an important role in the regulation of cell adhesion and embryonic development. In the absence of Wnt, it forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of beta-Catenin via BTRC and subsequent degradation by the proteasome. In the presence of Wnt ligand, beta-Catenin is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activation of Wnt responsive genes. beta-Catenin antibody (pAb) was raised in a Rabbit host. It has been validated for use in Immunoprecipitation and Western blot, it has been shown to react with Human samples.
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Aufreinigung
- Affinity Purified
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Immunogen
- This antibody was raised against a peptide within the N-terminal region of human beta-Catenin.
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Isotyp
- IgG
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anti-Catenin, beta (CATNB) (pSer33), (pSer37) antibody
CATNB Reaktivität: Human, Maus, Ratte WB, FACS, ELISA, IF (cc), IF (p), IHC (p), ICC, IHC (fro) Wirt: Kaninchen Polyclonal unconjugated
anti-Catenin, beta (CATNB) (AA 661-781) antibodyCATNB Reaktivität: Human, Maus, Ratte, Schwein, Zebrafisch (Danio rerio) WB, FACS, ELISA, IF (cc), IF (p), IHC (p), IHC (fro) Wirt: Kaninchen Polyclonal unconjugated
anti-Catenin, beta (CATNB) (C-Term) antibodyCATNB Reaktivität: Human, Maus, Ratte, Huhn, Rind (Kuh), Hund, Schwein, Kaninchen, Schaf, Affe, Hamster, Avian, Cat, Esel, Ziege, Meerschweinchen, Pferd WB, IF Wirt: Ziege Polyclonal unconjugated
anti-Catenin, beta (CATNB) (C-Term) antibodyCATNB Reaktivität: Human, Zebrafisch (Danio rerio) WB, IHC, ELISA Wirt: Kaninchen Polyclonal unconjugated
anti-Catenin, beta (CATNB) (pSer33), (pSer37), (pThr41) antibodyCATNB Reaktivität: Human, Maus, Ratte WB, IHC Wirt: Kaninchen Polyclonal unconjugated
anti-Catenin, beta (CATNB) (AA 439-675) antibodyCATNB Reaktivität: Human WB, IHC, IP, ICC Wirt: Kaninchen Polyclonal unconjugated
anti-Catenin, beta (CATNB) (AA 439-675) antibodyCATNB Reaktivität: Human WB, IHC, IP, ICC Wirt: Maus Monoclonal C11 unconjugated
anti-Catenin, beta (CATNB) antibodyCATNB Reaktivität: Human, Maus, Hamster WB, IP, ICC, ICFC Wirt: Maus Monoclonal EM-22 unconjugated
anti-Catenin, beta (CATNB) antibodyCATNB Reaktivität: Human, Maus, Ratte WB, IHC Wirt: Maus Monoclonal 4A3H3 unconjugated
anti-Catenin, beta (CATNB) (AA 764-781) antibodyCATNB Reaktivität: Human, Maus, Ratte WB, IHC (p), ICC, IHC (fro) Wirt: Kaninchen Polyclonal unconjugated
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Applikationshinweise
- Optimal working dilution should be determined by the investigator.
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Buffer
- Purified IgG in PBS with 30 % glycerol and 0.035 % sodium azide.
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Konservierungsmittel
- Sodium azide
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Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Lagerung
- -20 °C
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Informationen zur Lagerung
- Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.
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- beta Catenin (CATNB) (Catenin, beta (CATNB))
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Andere Bezeichnung
- beta-Catenin
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Molekulargewicht
- 90 kDa
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NCBI Accession
- NP_001895
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Pathways
- Peptide Hormone Metabolism
Target
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