PD-1 Antikörper
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- Target Alle PD-1 (PDCD1) Antikörper anzeigen
- PD-1 (PDCD1) (Programmed Cell Death 1 (PDCD1))
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Reaktivität
- Maus
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Wirt
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Armenischer Hamster
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Klonalität
- Monoklonal
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Konjugat
- Dieser PD-1 Antikörper ist unkonjugiert
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Applikation
- Flow Cytometry (FACS), Immunoprecipitation (IP), Immunohistochemistry (Frozen Sections) (IHC (fro)), Functional Studies (Func)
- Aufreinigung
- This monoclonal antibody preparation was purified from tissue culture supernatant via affinity chromatography. For In Vivo Ready™ (IVR) products, each preparation is also evaluated for endotoxin levels using the LAL assay. It is recommended to store the product undiluted at 4°C. Do not freeze.
- Endotoxin-Niveau
- Low endotoxin: < 0.01 EU/ug
- Klon
- J43-1
- Isotyp
- IgG
- Top Product
- Discover our top product PDCD1 Primärantikörper
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- Applikationshinweise
- This purified format is guaranteed to be >90 % pure as determined by SDS-PAGE analysis.
- Kommentare
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2.0 mg/mL
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Buffer
- 10 mM NaH2PO4, 150 mM NaCl, pH 7.2
- Konservierungsmittel
- Azide free
- Lagerung
- 4 °C
- Informationen zur Lagerung
- 2-8°C
- Haltbarkeit
- 12 months
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- Target
- PD-1 (PDCD1) (Programmed Cell Death 1 (PDCD1))
- Andere Bezeichnung
- CD279 (PD-1) (PDCD1 Produkte)
- Synonyme
- CD279 antikoerper, PD-1 antikoerper, PD1 antikoerper, SLEB2 antikoerper, hPD-1 antikoerper, hPD-l antikoerper, Ly101 antikoerper, Pdc1 antikoerper, programmed cell death 1 antikoerper, PDCD1 antikoerper, Pdcd1 antikoerper
- Hintergrund
- The J43.1 antibody is specific for mouse CD279, also known as programmed death-1 (PD-1), a 55 kDa glycoprotein which can co-regulate T cell antigen receptor signaling and therefore modulate T cell activation. PD-1 exists in a monomeric form that is expressed by CD4- CD8- thymocytes, where it participates in the processes of clonal selection, elimination of autoreactive lymphocytes, and development of tolerance. PD-1 expression is also inducible upon activation of mature T cells, where it has been proposed to interact with the co-stimulatory receptor CD80 to limit T cell activation. Two ligands for PD-1, known as PD-L1 (B7- H1) and PD-L2 (B7-DC) are differentially expressed on T and B cells, monocytes, macrophages, NK cells or dendritic cells. PD-1 is a member of a family of receptors including CD28 and CTLA-4 (CD152), which interact with ""B7"" ligands to provide a balance of co-stimulatory /co-inhibitory signaling important in T cell activation, tolerance, and autoimmunity.The J43.1 antibody may be used as a marker for PD-1 expression, and is commonly used for analysis of receptor-ligand interaction and function(s) in vitro and in vivo.
- Gen-ID
- 18566
- Pathways
- Cancer Immune Checkpoints
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