CSF1R Antikörper

Produktnummer ABIN6961453

Dieses Anti-CSF1R-Antikörper ist ein Ratte Monoklonal-Antikörper zur Detektion von CSF1R in WB, FACS und Func. Geeignet für Maus.

Kurzübersicht für CSF1R Antikörper (ABIN6961453)

Target: CSF1R (Colony Stimulating Factor 1 Receptor (CSF1R))

Reaktivität: Maus

Wirt: Ratte

Klonalität: Monoklonal

Konjugat: Dieser CSF1R Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Flow Cytometry (FACS), Functional Studies (Func)

Klon: AFS98

Produktdetails anti-CSF1R Antikörper

Aufreinigung: This monoclonal antibody preparation was purified from tissue culture supernatant via affinity chromatography. For In Vivo Ready™ (IVR) products, each preparation is also evaluated for endotoxin levels using the LAL assay. It is recommended to store the product undiluted at 4°C. Do not freeze.

Endotoxin-Niveau: Low endotoxin: < 0.01 EU/ug

Isotyp: IgG2a kappa

Anwendungsinformationen

Applikationshinweise: This purified format is guaranteed to be >90 % pure as determined by SDS-PAGE analysis.

Kommentare:

2 mg/mL

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: 10 mM NaH2PO4, 150 mM NaCl, pH 7.2

Konservierungsmittel: Azide free

Lagerung: 4 °C

Informationen zur Lagerung: 2-8°C

Haltbarkeit: 12 months

Details zu CSF1R

Target: CSF1R (Colony Stimulating Factor 1 Receptor (CSF1R))

Andere Bezeichnung: CD115 (c-fms)

Hintergrund: The AFS98 antibody is specific for mouse CD115, also known as Colony-Stimulating Factor-1 Receptor (CSF-1R), a 145 kDa receptor from the PDGF receptor family. Receptor activation by the ligands IL-34 or CSF-1 (M-CSF) occurs via homodimerization of CD115 and subsequent tyrosine phosphorylation and ubiquitination of intracellular domains. CD115 signaling promotes differentiation of myeloid pre- cursors, as well as the continued regulation of proliferation, survival and function of mononuclear phagocytes, dendritic cells and osteo- clasts. While IL-34 and CSF-1 may induce similar cellular responses, they are differentially expressed and as such exert complimentary actions via CD115.The AFS98 antibody may be used for identification of myeloid lineage cells by flow cytometry, and is commonly used for in vivo or in vitro neutralization of CSF-1 Receptor.

Gen-ID: 12978

UniProt: P09581

Pathways: RTK Signalweg, Inositol Metabolic Process, Cell-Cell Junction Organization