STAT2 Antikörper

Produktnummer ABIN6945063

Dieses Kaninchen Monoklonal-Antikörper erkennt spezifisch STAT2 in IHC (p) und IF (cc). Er zeigt eine Reaktivität gegenüber Human, Ratte und Maus.

Kurzübersicht für STAT2 Antikörper (ABIN6945063)

Target: STAT2 (Signal Transducer and Activator of Transcription 2, 113kDa (STAT2))

Reaktivität: Human, Ratte, Maus

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Dieser STAT2 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc))

Klon: 4B1

Produktdetails anti-STAT2 Antikörper

Kreuzreaktivität: Human, Maus, Ratte

Aufreinigung: Purified by Protein A.

Immunogen: Recombinant human STAT2 protein, around N-terminal 1-100aa.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IHC-P 1:200-400
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 1xTBS ( pH 7.4), 1 % BSA, 40 %Glycerol and 0.05 % Sodium Azide.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Details zu STAT2

Target: STAT2 (Signal Transducer and Activator of Transcription 2, 113kDa (STAT2))

Andere Bezeichnung: STAT2

Hintergrund:

Synonyms: P113, ISGF-3, STAT113, Signal transducer and activator of transcription 2, STAT2

Background: Signal transducer and activator of transcription that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with IRF9/ISGF3G to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state.

Gen-ID: 6773

UniProt: P52630

Pathways: JAK-STAT Signalweg, Hepatitis C, CXCR4-mediated Signaling Events