Rekombinanter Mre11 Antikörper (AA 450-550)

Produktnummer ABIN6944120

Der Kaninchen Monoklonal anti-Mre11 Antikörper (ABIN6944120) detektiert spezifisch Mre11 in WB, IF, IHC (p) und IHC (fro). Dieser Antikörper reagiert spezifisch mit Proben aus Human, Ratte und Maus.

Kurzübersicht für Rekombinanter Mre11 Antikörper (AA 450-550) (ABIN6944120)

Target: Mre11 (MRE11A) (MRE11 Meiotic Recombination 11 Homolog A (S. Cerevisiae) (MRE11A))

Antikörpertyp: Recombinant Antibody

Reaktivität: Human, Ratte, Maus

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Dieser Mre11 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Produktdetails anti-Mre11 Antikörper

Bindungsspezifität: AA 450-550

Verwendungszweck: Mre11 Recombinant Antibody

Kreuzreaktivität: Human, Maus, Ratte

Aufreinigung: Purified by Protein A.

Immunogen: Human Mre11 between 450-550 amino acids

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB(1:500-2000), IHC-P(1:50-200), IHC-F(1:400-800), IF(1:100-500)

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: 0.01M TBS ( pH 7.4), 1 % BSA, 0.02 % Proclin 300, and 50 % Glycerol

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C for 12 months.

Haltbarkeit: 12 months

Details zu Mre11

Target: Mre11 (MRE11A) (MRE11 Meiotic Recombination 11 Homolog A (S. Cerevisiae) (MRE11A))

Andere Bezeichnung: Mre11

Hintergrund:

Synonyms: Double-strand break repair protein MRE11, Double-strand break repair protein MRE11A, Meiotic recombination 11 homolog A, Meiotic recombination 11 homolog 1, MRE11 homolog 1, MRE11 homolog A, MRE11

Background: Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11A. RAD50 may be required to bind DNA ends and hold them in close proximity. This could facilitate searches for short or long regions of sequence homology in the recombining DNA templates, and may also stimulate the activity of DNA ligases and/or restrict the nuclease activity of MRE11A to prevent nucleolytic degradation past a given point. The complex may also be required for DNA damage signaling via activation of the ATM kinase. In telomeres the MRN complex may modulate t-loop formation.

Gen-ID: 4361

UniProt: P49959

Pathways: DNA Reparatur