Rekombinanter LOXL2 Antikörper (C-Term)

Produktnummer ABIN6943946

Der Kaninchen Monoklonal anti-LOXL2 Antikörper (ABIN6943946) detektiert spezifisch LOXL2 in WB. Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für Rekombinanter LOXL2 Antikörper (C-Term) (ABIN6943946)

Target: LOXL2 (Lysyl Oxidase-Like 2 (LOXL2))

Antikörpertyp: Recombinant Antibody

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Dieser LOXL2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-LOXL2 Antikörper

Bindungsspezifität: C-Term

Verwendungszweck: LOXL2 Recombinant Antibody

Kreuzreaktivität: Human

Aufreinigung: Purified by Protein A.

Immunogen: Synthetic peptide within Human LOXL2 aa 750 to the C-terminus

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB(WB(1:500-2000))

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: 0.01M TBS ( pH 7.4), 1 % BSA, 0.02 % Proclin 300, and 50 % Glycerol

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C for up to 2 weeks. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Haltbarkeit: 12 months

Details zu LOXL2

Target: LOXL2 (Lysyl Oxidase-Like 2 (LOXL2))

Andere Bezeichnung: LOXL2

Hintergrund:

Synonyms: Lysyl oxidase homolog 2, Lysyl oxidase-like protein 2, Lysyl oxidase-related protein 2, Lysyl oxidase-related protein WS9-14, LOXL2,

Background: Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine). When secreted in the extracellular matrix, promotes cross-linking of extracellular matrix proteins by mediating oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. Acts as a regulator of sprouting angiogenesis, probably via collagen IV scaffolding. When nuclear, acts as a transcription corepressor and specifically mediates deamination of trimethylated 'Lys-4' of histone H3 (H3K4me3), a specific tag for epigenetic transcriptional activation. Involved in epithelial to mesenchymal transition (EMT) via interaction with SNAI1 and participates in repression of E-cadherin, probably by mediating deamination of histone H3. Also involved in E-cadherin repression following hypoxia, a hallmark of epithelial to mesenchymal transition believed to amplify tumor aggressiveness, suggesting that it may play a role in tumor progression. Acts as a regulator of chondrocyte differentiation, probably by regulating the expression of factors that control chondrocyte differentiation.

Gen-ID: 4017

UniProt: Q9Y4K0

Pathways: Chromatin Binding