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HNRNPC Antikörper

HNRNPC Reaktivität: Human, Ratte, Maus, Zebrafisch (Danio rerio) WB, IHC, IHC (p), IF (cc), FACS Wirt: Kaninchen Monoclonal 9F7 unconjugated
Produktnummer ABIN6943686
  • Target Alle HNRNPC Antikörper anzeigen
    HNRNPC (Heterogeneous Nuclear Ribonucleoprotein C (C1/C2) (HNRNPC))
    Reaktivität
    • 57
    • 48
    • 33
    • 8
    • 7
    • 6
    • 6
    • 6
    • 5
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Human, Ratte, Maus, Zebrafisch (Danio rerio)
    Wirt
    • 70
    • 2
    Kaninchen
    Klonalität
    • 62
    • 10
    Monoklonal
    Konjugat
    • 38
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser HNRNPC Antikörper ist unkonjugiert
    Applikation
    • 42
    • 26
    • 25
    • 15
    • 15
    • 13
    • 13
    • 7
    • 3
    • 3
    • 3
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Flow Cytometry (FACS)
    Kreuzreaktivität
    Human, Maus, Ratte, Zebrafisch (Danio rerio)
    Aufreinigung
    Purified by Protein A.
    Immunogen
    Full length protein
    Klon
    9F7
    Isotyp
    IgG
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  • Applikationshinweise
    WB 1:300-5000
    FCM 1:20-100
    IHC-P 1:200-400
    IF(ICC) 1:50-200
    IHC()
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 1xTBS ( pH 7.4), 1 % BSA, 40 %Glycerol and 0.05 % Sodium Azide.
    Konservierungsmittel
    ProClin
    Vorsichtsmaßnahmen
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20°C for 12 months.
    Haltbarkeit
    12 months
  • Target
    HNRNPC (Heterogeneous Nuclear Ribonucleoprotein C (C1/C2) (HNRNPC))
    Andere Bezeichnung
    hnRNP C1+C2 (HNRNPC Produkte)
    Hintergrund

    Synonyms: Heterogeneous nuclear ribonucleoproteins C1/C2, hnRNP C1/C2, HNRNPC

    Background: Binds pre-mRNA and nucleates the assembly of 40S hnRNP particles (PubMed:8264621). Interacts with poly-U tracts in the 3'-UTR or 5'-UTR of mRNA and modulates the stability and the level of translation of bound mRNA molecules (PubMed:12509468, PubMed:16010978, PubMed:7567451, PubMed:8264621). Single HNRNPC tetramers bind 230-240 nucleotides. Trimers of HNRNPC tetramers bind 700 nucleotides (PubMed:8264621). May play a role in the early steps of spliceosome assembly and pre-mRNA splicing. N6-methyladenosine (m6A) has been shown to alter the local structure in mRNAs and long non-coding RNAs (lncRNAs) via a mechanism named 'm6A-switch', facilitating binding of HNRNPC, leading to regulation of mRNA splicing (PubMed:25719671).

    Gen-ID
    3183
    UniProt
    P07910
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