VEGFR2/CD309 Antikörper

Produktnummer ABIN6941304

Der Ratte Monoklonal Anti-VEGFR2/CD309-Antikörper wurde für WB, Neut und Bind validiert. Er ist geeignet, VEGFR2/CD309 in Proben von Maus zu detektieren.

Kurzübersicht für VEGFR2/CD309 Antikörper (ABIN6941304)

Target: VEGFR2/CD309 (VEGFR2) (VEGF Receptor 2 (VEGFR2))

Reaktivität: Maus

Wirt: Ratte

Klonalität: Monoklonal

Konjugat: Dieser VEGFR2/CD309 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Neutralization (Neut), Binding Studies (Bind)

Klon: DC101

Produktdetails anti-VEGFR2/CD309 Antikörper

Spezifität: This MAb is specific to Mouse VEGFR2/FLK-1/CD309 and does not cross-react with FLK-2. VEGFR2 is a type I transmembrane glycoprotein. It is a member of the CSF-1/PDGF receptor family of type III tyrosine kinase receptors. Endothelial cells, embryonic tissues, and megakaryocytes mainly express VEGFR2. It plays an important role in the regulation of angiogenesis, vasculogenesis, and vascular permeability. The ligands of VEGFR2 include VEGF-A, VEGF-C, VEGF-D, and VEGF splice isoforms. Ligation of VEGFR2 with its ligands results in the receptor dimerization and auto-phosphorylation, stimulating endothelial cell proliferation and migration.

Aufreinigung: Purified by Protein A/G

Immunogen: Recombinant full-length Mouse VEGFR2 protein

Isotyp: IgG1 kappa

Anwendungsinformationen

Applikationshinweise:

Positive Control: Mouse epidermoid, renal cell carcinoma, pancreatic or glioblastoma cells.

Known Application: Western Blot (Non-reducing) (2-5 μg/mL), Blocks Binding of VEGF to VEGF-R2 (Order Ab without BSA & Azide), Inhibits VEGF-induced Signaling (Order Ab without BSA & Azide), Blocks Tumor Growth in mice (Order Ab without BSA & Azide), Neutralizing, Optimal dilution for a specific application should be determined.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 200 μg/mL

Buffer: 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-80 °C

Informationen zur Lagerung: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Haltbarkeit: 24 months

Details zu VEGFR2/CD309

Target: VEGFR2/CD309 (VEGFR2) (VEGF Receptor 2 (VEGFR2))

Andere Bezeichnung: Kdr

Molekulargewicht: 180-190kDa

Gen-ID: 16542, 35918

Pathways: RTK Signalweg, Glycosaminoglycan Metabolic Process, Signaling Events mediated by VEGFR1 and VEGFR2, Growth Factor Binding, Regulation of long-term Neuronal Synaptic Plasticity, VEGF Signaling