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CD74 Antikörper

Der Maus Monoklonal Anti-CD74-Antikörper wurde für FACS, IF, IHC und StM validiert. Er ist geeignet, CD74 in Proben von Human zu detektieren.
Produktnummer ABIN6941256

Kurzübersicht für CD74 Antikörper (ABIN6941256)

Target

Alle CD74 Antikörper anzeigen
CD74 (HLA-DR-gamma (CD74))

Reaktivität

  • 209
  • 82
  • 21
  • 16
Human

Wirt

  • 127
  • 105
  • 4
  • 3
  • 2
Maus

Klonalität

  • 157
  • 80
  • 3
Monoklonal

Konjugat

  • 86
  • 18
  • 15
  • 10
  • 9
  • 7
  • 6
  • 5
  • 5
  • 5
  • 5
  • 5
  • 5
  • 5
  • 4
  • 4
  • 4
  • 3
  • 3
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
Dieser CD74 Antikörper ist unkonjugiert

Applikation

  • 143
  • 134
  • 84
  • 58
  • 44
  • 41
  • 36
  • 27
  • 15
  • 13
  • 13
  • 13
  • 11
  • 10
  • 5
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
Flow Cytometry (FACS), Immunofluorescence (IF), Immunohistochemistry (IHC), Staining Methods (StM)

Klon

CLIP-813
  • Spezifität

    It recognizes a protein of ~35 kDa, identified as CD74. It is a type II transmembrane protein which binds to the peptide binding groove of newly synthesized MHC class II alpha/beta heterodimers and prevents their premature association with endogenous polypeptides. CD74 is expressed primarily by antigen presenting cells, such as B-lymphocytes (from before the pre-B cell stage to before the plasma cell stage), macrophages, and monocytes, and many epithelial cells. Anti-CD74 stains predominantly germinal center lymphocytes and B-cell lymphomas, but rarely T-cell lymphomas. Anti-CD74 has been shown to be useful in differentiating atypical fibroxanthoma (-) from malignant fibrous histiocytoma (+).

    Aufreinigung

    Purified by Protein A/G

    Immunogen

    Recombinant full-length human CD74 protein

    Isotyp

    IgG1 kappa
  • Applikationshinweise

    Positive Control: Daudi or Raji cells. Tonsil or lymph node.

    Known Application: Flow Cytometry (1-2 μg/million cells) (Methanol Fixed), ,Immunofluorescence (1-2 μg/mL), ,Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT),(Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes),Optimal dilution for a specific application should be determined.

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Konzentration

    200 μg/mL

    Buffer

    10 mM PBS with 0.05 % BSA & 0.05 % azide.

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    4 °C,-80 °C

    Informationen zur Lagerung

    Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

    Haltbarkeit

    24 months
  • Target

    CD74 (HLA-DR-gamma (CD74))

    Andere Bezeichnung

    CD74

    Molekulargewicht

    33-41kDa

    Gen-ID

    972

    Pathways

    Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Negative Regulation of intrinsic apoptotic Signaling, Cancer Immune Checkpoints
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