TSHB Antikörper

Produktnummer ABIN6940810

Dieses Maus Monoklonal-Antikörper erkennt spezifisch TSHB in IHC, ISt und StM. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für TSHB Antikörper (ABIN6940810)

Target: TSHB (Thyroid Stimulating Hormone, beta (TSHB))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser TSHB Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC), Immunostaining (ISt), Staining Methods (StM)

Klon: TSHb-1317

Produktdetails anti-TSHB Antikörper

Aufreinigung: Purified by Protein A/G

Immunogen: Recombinant human TSH beta fragment

Isotyp: IgG1 kappa

Anwendungsinformationen

Applikationshinweise:

Positive Control: Normal pituitary or its tumor.

Known Application: Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT)(Staining of formalin-fixed tissues is enhanced by boiling tissue sections in 10 mM Citrate Buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes)Optimal dilution for a specific application should be determined.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 200 μg/mL

Buffer: 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Antibody with azide - store at 2 to 8°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Haltbarkeit: 24 months

Details zu TSHB

Target: TSHB (Thyroid Stimulating Hormone, beta (TSHB))

Andere Bezeichnung: TSHB

Hintergrund: The four human glycoprotein hormones chorionic gonadotropin (CG), luteinizing hormone (LH) follicle stimulating hormone (FSH), and thyroid stimulating hormone (TSH) are dimers consisting of alpha and beta subunits that are associated non-covalently. The alpha subunits of these hormones are identical, however, their beta chains are unique and confer biological specificity. TSH is synthesized and secreted by thyrotrope cells in the anterior pituitary gland which regulates the endocrine function of the thyroid gland. TSH stimulates the thyroid gland to secrete the hormones thyroxine (T4) and triiodothyronine (T3). TSH production is controlled by a Thyrotropin-Releasing Hormone (TRH), which is manufactured in the hypothalamus and transported to the pituitary gland, where it increases TSH production and release. Somatostatin is also produced by the hypothalamus and has an opposite effect on the pituitary production of TSH, decreasing or inhibiting its release. TSH is a useful marker in classification of pituitary tumors and the study of pituitary disease.

Molekulargewicht: 16kDa

Gen-ID: 7252

UniProt: P01222

Pathways: Thyroid Hormone Synthesis, Peptide Hormone Metabolism