Cyclin D1 Antikörper (AA 115-270)
Kurzübersicht für Cyclin D1 Antikörper (AA 115-270) (ABIN6940490)
Target
Alle Cyclin D1 (CCND1) Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
Klon
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Bindungsspezifität
- AA 115-270
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Spezifität
- Recognizes a protein of 36 kDa, identified as cyclin D1. Cyclin D1, one of the key cell cycle regulators, is a putative proto-oncogene overexpressed in a wide variety of human neoplasms. This antibody neutralizes the activity of cyclin D1 in vivo. About 60 % of mantle cell lymphomas (MCL) contain a t(11, 14)(q13, q32) translocation resulting in over-expression of cyclin D1. This antibody is useful in identifying mantle cell lymphomas (cyclin D1 positive) from CLL/SLL and follicular lymphomas (cyclin D1 negative). Occasionally, hairy cell leukemia and plasma cell myeloma weakly express Cyclin D1.
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Aufreinigung
- Purified by Protein A/G
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Immunogen
- Recombinant fragment of human CCND1 (around aa 115-270) protein (exact sequence is proprietary)
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Isotyp
- IgG2b kappa
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anti-Cyclin D1 (CCND1) (AA 61-110) antibody
CCND1 Reaktivität: Human, Maus, Ratte, Rind (Kuh), Kaninchen, Schaf WB, ELISA, FACS, IHC (p), IF (cc), IF (p), IHC (fro) Wirt: Kaninchen Polyclonal unconjugated
anti-Cyclin D1 (CCND1) (AA 68-97) antibodyCCND1 Reaktivität: Human, Maus WB, IF, IHC (p) Wirt: Kaninchen Polyclonal RB8066 unconjugated
anti-Cyclin D1 (CCND1) (C-Term) antibodyCCND1 Reaktivität: Human WB, IHC, IF, IP Wirt: Kaninchen Polyclonal unconjugated
anti-Cyclin D1 (CCND1) antibodyKO Validated CCND1 Reaktivität: Human WB, IHC, IF, IP Wirt: Kaninchen Monoclonal unconjugated
anti-Cyclin D1 (CCND1) (AA 167-295) antibodyCCND1 Reaktivität: Human IHC, ELISA, FACS, ICC Wirt: Maus Monoclonal 3B6G3 unconjugated
anti-Cyclin D1 (CCND1) (AA 1-295) antibodyCCND1 Reaktivität: Human, Maus WB, IHC, ELISA, FACS Wirt: Maus Monoclonal 1F7F5 unconjugated
anti-Cyclin D1 (CCND1) (C-Term) antibodyCCND1 Reaktivität: Human, Maus, Ratte WB, IHC, ELISA, IF, ICC Wirt: Kaninchen Polyclonal unconjugated
anti-Cyclin D1 (CCND1) (AA 68-97) antibodyCCND1 Reaktivität: Human, Maus WB, IHC, ELISA, IF Wirt: Kaninchen Polyclonal unconjugated
anti-Cyclin D1 (CCND1) (C-Term) antibodyCCND1 Reaktivität: Human WB, IF, IP Wirt: Kaninchen Polyclonal unconjugated
anti-Cyclin D1 (CCND1) antibodyCCND1 Reaktivität: Human, Maus, Ratte, Affe WB, IHC, FACS, IF, StM Wirt: Maus Monoclonal DCS-6 unconjugated
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Applikationshinweise
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Positive Control: T47D, ZR75, BT474, SKBR3, MCF-7, MDA-MB-453, HT29, Ramos, Jurkat or A431 cells. Mantle cell lymphoma, breast or bladder carcinomas.
Known Application: ELISA (For coating, order Ab without BSA), Optimal dilution for a specific application should be determined.
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Konzentration
- 200 μg/mL
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Buffer
- 10 mM PBS with0.05 % BSA & 0.05 % azide.
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Konservierungsmittel
- Sodium azide
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Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Lagerung
- 4 °C,-80 °C
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Informationen zur Lagerung
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
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Haltbarkeit
- 24 months
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- Cyclin D1 (CCND1)
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Andere Bezeichnung
- CCND1
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Molekulargewicht
- 36kDa
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Gen-ID
- 595
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UniProt
- P24385
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Pathways
- PI3K-Akt Signalweg, Zellzyklus, Mitotic G1-G1/S Phases, ER-Nucleus Signaling
Target
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