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RAD51 Antikörper (AA 1-134)

Der Maus Monoklonal Anti-RAD51-Antikörper wurde für WB, ELISA und Coat validiert. Er ist geeignet, RAD51 in Proben von Human zu detektieren.
Produktnummer ABIN6940477

Kurzübersicht für RAD51 Antikörper (AA 1-134) (ABIN6940477)

Target

Alle RAD51 Antikörper anzeigen
RAD51 (DNA Repair Protein Homolog 1 (RAD51))

Reaktivität

  • 125
  • 76
  • 38
  • 4
  • 4
  • 3
  • 3
  • 3
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
Human

Wirt

  • 107
  • 21
  • 1
Maus

Klonalität

  • 98
  • 31
Monoklonal

Konjugat

  • 74
  • 5
  • 4
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
Dieser RAD51 Antikörper ist unkonjugiert

Applikation

  • 96
  • 39
  • 29
  • 29
  • 28
  • 22
  • 21
  • 21
  • 11
  • 11
  • 9
  • 3
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
Western Blotting (WB), ELISA, Coating (Coat)

Klon

RAD51-2753
  • Bindungsspezifität

    • 23
    • 15
    • 11
    • 7
    • 7
    • 6
    • 5
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 1-134

    Aufreinigung

    Purified by Protein A/G

    Immunogen

    Recombinant fragment of human RAD51 protein (around aa 1-134) (exact sequence is proprietary)

    Isotyp

    IgG
  • Applikationshinweise

    Positive Control: HeLa or MCF-7 cells. Colon or breast Carcinoma.

    Known Application: ELISA (For coating, order Ab without BSA),Western Blot (1-2 μg/mL)Optimal dilution for a specific application should be determined.

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Konzentration

    200 μg/mL

    Buffer

    10 mM PBS with 0.05 % BSA & 0.05 % azide.

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    4 °C,-80 °C

    Informationen zur Lagerung

    Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

    Haltbarkeit

    24 months
  • Target

    RAD51 (DNA Repair Protein Homolog 1 (RAD51))

    Andere Bezeichnung

    RAD51

    Hintergrund

    RAD51 is one of the key factors of DNA repair by homologous recombination and has been shown to have anti-apoptotic activity in tumor cells. RAD51 protein interacts with a variety of tumor suppressor proteins including p53, BRCA1 and BRCA2. Elevated expression of RAD51 enhances radio-resistance of human tumor cells. Overexpression of RAD51 protein in tumor cells renders them resistant against cytotoxic drugs like Cisplatin. RAD51 interacts with BRCA1 and BRCA2 to influence subcellular localization and cellular response to DNA damage. BRCA2 inactivation may be a key event leading to genomic instability and tumorigenesis from deregulation of RAD51. High-level expression of RAD51 has been observed in a variety of human malignancies.RAD51 overexpression correlates with histological grading of the tumor in invasive ductal mammary carcinoma.

    Molekulargewicht

    37kDa

    Gen-ID

    5888

    UniProt

    Q06609

    Pathways

    DNA Reparatur
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